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Test ID ALS Aldolase, Serum

Reporting Name

Aldolase, S

Useful For

Detection of muscle disease

Specimen Type

Serum Red


Specimen Required


Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 7 days
  Frozen  14 days

Reference Values

0-16 years: <14.5 U/L

≥17 years: <7.7 U/L

Day(s) and Time(s) Performed

Monday through Saturday; Continuously

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82085

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ALS Aldolase, S 1761-6

 

Result ID Test Result Name Result LOINC Value
ALS Aldolase, S 1761-6

Clinical Information

Aldolase is necessary for glycolysis in muscle as a "rapid response" pathway for production of adenosine triphosphate, independent of tissue oxygen.

 

Aldolase catalyses the conversion of fructose 1,6-diphosphate into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate, an important reaction in the glycolytic breakdown of glucose to lactate in muscle.

 

Aldolase is a tetramer whose primary structure depends upon the tissue from which it was synthesized (liver, muscle, brain). The brain form of aldolase has, because of its preponderance in white cells, been suggested to be a leukemia marker, but this is not confirmed.

 

Elevated values are found in muscle diseases, such as Duchenne muscular dystrophy, dermatomyositis, polymyositis, and limb-girdle dystrophy.

Interpretation

The highest levels of aldolase are found in progressive (Duchenne) muscular dystrophy. Lesser elevations are found in dermatomyositis, polymyositis, and limb-girdle dystrophy. In dystrophic conditions causing hyperaldolasemia, the increase in aldolase becomes less dramatic as muscle mass decreases.

 

Reference (normal) values are observed in polio, myasthenia gravis, and multiple sclerosis.

 

Aldolase increases in myocardial infarction in a time pattern similar to the aspartate aminotransferase.

 

Increases are also associated with acute viral hepatitis, but levels are normal or slightly elevated in chronic hepatitis, portal cirrhosis, and obstructive jaundice.

 

Elevations may also be seen with gangrene, prostate tumors, trichinosis, some carcinomas metastatic to the liver, some chronic leukemias, some blood dyscrasias, and delirium tremens.

Analytic Time

1 day (not reported on Sunday)

Method Name

Ultraviolet, Kinetic

Forms

If not ordering electronically, complete, print, and send a General Request Form (T239) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/general-request-form.pdf).