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Test ID CBC CBC with Differential, Blood

Reporting Name

CBC with Differential, B

Useful For

A screening tool to confirm a hematologic disorder, to establish or rule out a diagnosis, to detect an unsuspected hematologic disorder, or to monitor effects of radiation or chemotherapy

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
DIFFR Morphology Eval (special Smear) No No

Testing Algorithm

An approval will be requested before the morphologic evaluation is ordered due to the additional charge.

Specimen Type

Whole Blood EDTA


Shipping Instructions


Specimen must arrive within 24 hours of draw.



Necessary Information


 



Specimen Required


Container/Tube: Lavender top (EDTA)

Specimen Volume: 3 mL


Specimen Minimum Volume

1.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Whole Blood EDTA Refrigerated (preferred) 24 hours
  Ambient  24 hours

Reference Values

RED BLOOD CELL COUNT (RBC)

Males:

Birth: 3.90-5.50 x 10(12)/L

1-7 days: 3.90-6.00 x 10(12)/L

8-14 days: 3.60-6.00 x 10(12)/L

15 days-1 month: 3.00-5.50 x 10(12)/L

2-5 months: 3.10-4.50 x 10(12)/L

6 months-1 year: 3.70-6.00 x 10(12)/L

2 years: 4.10-5.10 x 10(12)/L

3-5 years: 4.10-5.30 x 10(12)/L

6-11 years: 4.20-5.10 x 10(12)/L

12-15 years: 4.40-5.50 x 10(12)/L

Adults: 4.32-5.72 x 10(12)/L

 

Females:

Birth: 3.90-5.50 x 10(12)/L

1-7 days: 3.90-6.00 x 10(12)/L

8-14 days: 3.60-6.00 x 10(12)/L

15 days-1 month: 3.00-5.50 x 10(12)/L 

2-5 months: 3.10-4.50 x 10(12)/L

6 months-1 year: 3.70-6.00 x 10(12)/L

2 years: 4.10-5.10 x 10(12)/L 

3-5 years: 4.10-5.20 x 10(12)/L

6-11 years: 4.10-5.30 x 10(12)/L

12-15 years: 4.10-5.20 x 10(12)/L

Adults: 3.90-5.03 x 10(12)/L

 

HEMOGLOBIN

Males:

Birth-7 days: 13.5-22.0 g/dL

8-14 days: 12.5-21.0 g/dL

15 days-1 month: 10.0-20.0 g/dL

2-5 months: 10.0-14.0 g/dL

6 months-1 year: 10.5-13.5 g/dL

2 years: 11.0-14.0 g/dL

3-5 years: 11.0-14.5 g/dL

6-11 years: 12.0-14.0 g/dL

12-15 years: 12.8-16.0 g/dL

Adults: 13.5-17.5 g/dL

 

Females:

Birth-7 days: 13.5-22.0 g/dL

8-14 days: 12.5-21.0 g/dL

15 days-1 month: 10.0-20.0 g/dL

2-5 months: 10.0-14.0 g/dL

6 months-1 year: 10.5-13.5 g/dL

2 years: 11.0-14.0 g/dL 

3-5 years: 11.8-14.7 g/dL

6-11 years: 12.0-14.5 g/dL

12-15 years: 12.2-14.8 g/dL

Adults: 12.0-15.5 g/dL

 

HEMATOCRIT

Males:

Birth-7 days: 42.0-60.0%

8-14 days: 39.0-60.0%

15 days-1 month: 31.0-55.0%

2-5 months: 28.0-42.0%

6 months-1 year: 33.0-40.0%

2 years: 33.0-42.0%

3-5 years: 33.0-43.0%

6-11 years: 35.8-42.4%

12-15 years: 37.3-47.3%

Adults: 38.8-50.0%

 

Females:

Birth-7 days: 42.0-60.0%

8-14 days: 39.0-60.0%

15 days-1 month: 31.0-55.0% 

2-5 months: 28.0-42.0%

6 months-1 year: 33.0-40.0%

2 years: 33.0-42.0%

3-5 years: 35.0-44.0%

6-11 years: 35.7-43.0%

12-15 years: 36.3-43.4%

Adults: 34.9-44.5%

 

MEAN CORPUSCULAR VOLUME (MCV)

Males:

Birth: 98.0-120.0 fL

1-7 days: 88.0-120.0 fL

8-14 days: 86.0-120.0 fL

15 days-1 month: 85.0-110.0 fL 

2-5 months: 77.0-110.0 fL

6 months-5 years: 74.0-89.0 fL

6-11 years: 76.5-90.6 fL

12-15 years: 81.4-91.9 fL

Adults: 81.2-95.1 fL

 

Females:

Birth: 98.0-120.0 fL

1-7 days: 88.0-120.0 fL

8-14 days: 86.0-120.0 fL

15 days-1 month: 85.0-110.0 fL 

2-5 months: 77.0-110.0 fL

6 months-5 years: 74.0-89.0 fL

6-11 years: 78.5-90.4 fL

12-15 years: 79.9-92.3 fL

Adults: 81.6-98.3 fL

 

RED CELL DISTRIBUTION WIDTH (RDW)

Males:

<2 years: not established 

2 years: 12.0-14.5%

3-5 years: 12.0-14.0%

6-11 years: 12.0-14.0%

12-15 years: 11.6-13.8%

Adults: 11.8-15.6%

Females:

<2 years: not established

2 years: 12.0-14.5%

3-5 years: 12.0-14.0%

6-11 years: 11.6-13.4%

12-15 years: 11.2-13.5%

Adults: 11.9-15.5%

 

WHITE BLOOD CELL COUNT (WBC)

Males:

Birth: 9.0-30.0 x 10(9)/L

1-7 days: 9.4-34.0 x 10(9)/L

8-14 days: 5.0-21.0 x 10(9)/L

15 days-1 month: 5.0-20.0 x 10(9)/L

2-5 months: 5.0-15.0 x 10(9)/L

6 months-1 year: 6.0-11.0 x 10(9)/L

2 years: 5.0-12.0 x 10(9)/L

3-5 years: 4.0-12.0 x 10(9)/L

6-11 years: 3.4-9.5 x 10(9)/L

12-15 years: 3.6-9.1 x 10(9)/L

Adults: 3.5-10.5 x 10(9)/L

 

Females:

Birth: 9.0-30.0 x 10(9)/L

1-7 days: 9.4-34.0 x 10(9)/L

8-14 days: 5.0-21.0 x 10(9)/L

15 days-1 month: 5.0-20.0 x 10(9)/L

2-5 months: 5.0-15.0 x 10(9)/L

6 months-1 year: 6.0-11.0 x 10(9)/L

2 years: 5.0-12.0 x 10(9)/L

3-5 years: 4.0-12.0 x 10(9)/L

6-11 years: 3.4-10.8 x 10(9)/L

12-15 years: 4.1-8.9 x 10(9)/L

Adults: 3.5-10.5 x 10(9)/L

 

PLATELETS

Birth-5 months: 150-350 x 10(9)/L

≥6 months: 150-450 x 10(9)/L

 

NEUTROPHILS

Birth: 6.00-26.00 x 10(9)/L

1-7 days: 1.50-10.00 x 10(9)/L

8-14 days: 1.00-9.50 x 10(9)/L

15 days-1 month: 1.00-9.00 x 10(9)/L

2-5 months: 1.00-8.50 x 10(9)/L

6 months-5 years: 1.50-8.50 x 10(9)/L

6-11 years: 1.50-8.50 x 10(9)/L    

12-15 years: 1.80-8.00 x 10(9)/L

Adults: 1.70-7.00 x 10(9)/L

 

LYMPHOCYTES

Birth: 2.00-11.00 x 10(9)/L

1-14 days: 2.00-17.00 x 10(9)/L 

15 days-1 month: 2.50-16.50 x 10(9)/L

2-5 months: 4.00-13.50 x 10(9)/L

6 months-11 months: 4.00-10.50 x 10(9)/L

1-5 years: 1.50-7.00 x 10(9)/L

6-11 years: 1.50-6.50 x 10(9)/L

12-15 years: 1.20-5.20 x 10(9)/L

Adults: 0.90-2.90 x 10(9)/L

 

MONOCYTES

Birth-14 days: 0.40-1.80 x 10(9)/L

15 days-11 months: 0.05-1.10 x 10(9)/L

1-15 years: 0.00-0.80 x 10(9)/L

Adults: 0.30-0.90 x 10(9)/L

 

EOSINOPHILS

Birth-5 months: 0.02-0.85 x 10(9)/L

6 months-11 months: 0.05-0.70 x 10(9)/L

1-5 years: 0.00-0.65 x 10(9)/L

6-15 years: 0.00-0.50 x 10(9)/L

Adults: 0.05-0.50 x 10(9)/L

 

BASOPHILS

Birth-5 months: 0.00-0.60 x 10(9)/L

6 months-15 years: 0.00-0.20 x 10(9)/L 

≥16 years: 0.00-0.30 x 10(9)/L

Day(s) and Time(s) Performed

Monday through Sunday; Continuously

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

85025-CBC

85007-Differential (if appropriate)

85060-Hematopathology consultation (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CBC CBC with Differential, B 57021-8

 

Result ID Test Result Name Result LOINC Value
HGB Hemoglobin 718-7
HCT Hematocrit 4544-3
RBC Erythrocytes 789-8
MCV MCV 787-2
RDW RBC Distrib Width 788-0
WBC Leukocytes 6690-2
NEUAA Neutrophils 751-8
LYMAA Lymphocytes 731-0
MONAA Monocytes 742-7
EOSAA Eosinophils 711-2
BASAA Basophils 704-7
PLTC Platelet Count 777-3

Clinical Information

RBCs, WBCs, and platelets are produced in the bone marrow and released into the peripheral blood. The primary function of the RBC is to deliver oxygen to tissues. WBCs are key components of the immune system. Platelets play a vital role in blood clotting.

 

Mean corpuscular volume (MCV) is a measure of the size of the average RBC. Anemias are characterized as microcytic (MCV <80), macrocytic (MCV >100), or normocytic. The red cell distribution width (RDW) is a measure of the degree of variation in RBC size (anisocytosis). RDW may be helpful in distinguishing between some anemias. For example, iron deficiency anemia is characterized by a high RDW, while thalassemia is characterized by a low RDW.

 

These counts are used as clinical guides in the diagnosis or monitoring of many diseases.

Interpretation

Results outside of normal value ranges may reflect a primary disorder of the cell-producing organs or an underlying disease. Results should be interpreted in conjunction with the patient's clinical picture and appropriate additional testing performed.

Clinical Reference

1. Johnson M, Samuels C, Jozsa N, Gorney K: Three-way evaluation of high-throughput hematology analyzers-Beckman Coulter LH750, Abbott Cell-Dyn 4000, and Sysmex XE2100. Lab Hematol 2002;8:230-238

2. Klee G: Decision rules for accelerated hematology laboratory investigation. University of Minnesota 1974;thesis (PhD)

3. McKenzie SB: Textbook of Hematology. Lea and Febiger, Philadelphia 1988

4. Orkin SH, Fisher DE, Ginsburg D, et al: Nathan and Oski’s Hematology and Oncology of Infancy and Childhood. Edited by ST Orkin, DE Fisher, AT Look, et al. WB Saunders Co, Philadelphia, 1981

Analytic Time

Same day/1 day

Method Name

RF/DC (Radio Frequency/Direct Current) Detection/Hydro Dynamic Focusing (DC Detection), Flow Cytometry (Using a Semiconductor Laser)/Sodium Lauryl Sulfate (SLS) Hemoglobin