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Test ID HYPS Hypersensitivity Pneumonitis Panel, IgG, Serum

Useful For

Evaluation of patients suspected of having hypersensitivity pneumonitis induced by exposure to Aspergillus fumigatus, Thermoactinomyces vulgaris, or Micropolyspora faeni

Profile Information

Test ID Reporting Name Available Separately Always Performed
MPSF Micropolyspora faeni, IgG Ab, S Yes Yes
SASP Aspergillus fumigatus, IgG Ab, S Yes Yes
TAMV Thermoactinomyces vulgaris, IgG Ab Yes Yes

Method Name

Fluorescence Enzyme Immunoassay (FEIA)

Reporting Name

Hypersensitivity Pneum Panel, IgG,S

Specimen Type

Serum


Specimen Required


Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.5 mL


Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Clinical Information

Hypersensitivity pneumonitis (HP) is a heterogeneous disease caused by exposure to organic dust antigens, animal proteins, chemicals, medications, or microorganisms (eg, Thermoactinomyces vulgaris, Micropolyspora faeni, Aspergillus fumigatus). The immunopathogenesis of disease is not known; but, several immunologic mechanisms may play a role in producing alveolitis, including cellular immunity mediated by CD4 and CD8 T lymphocytes, immune-complex mediated inflammation, complement activation or activation of alveolar macrophages.(1)

 

HP is suspected clinically in patients who present with intermittent or progressive pulmonary symptoms and interstitial lung disease. The diagnosis is established by compatible clinical and radiographic findings, pulmonary function tests, and demonstration of specific antibodies to organic antigens known to cause the disease.

Reference Values

Aspergillus fumigatus, IgG ANTIBODIES

<4 years: not established

≥4 years: ≤102 mg/L

Micropolyspora faeni, IgG ANTIBODIES

0-12 years: ≤4.9 mg/L

13-18 years: ≤9.1 mg/L

>18 years: ≤13.2 mg/L

 

Thermoactinomyces vulgaris, IgG ANTIBODIES

0-12 years: ≤6.6 mg/L

13-18 years: ≤11.0 mg/L

>18 years: ≤23.9 mg/L

Interpretation

Elevated concentrations of IgG antibodies to Aspergillus fumigatus, Thermoactinomyces vulgaris, or Micropolyspora faeni in patients with signs and symptoms of hypersensitivity pneumonitis may be consistent with disease caused by exposure to 1 or more of these organic antigens.

Clinical Reference

1. Fink JN, Zacharisen MC: Chapter 69: Hypersensitivity pneumonitis. In Allergy Principles and Practice. Vol 1. Fifth edition. Edited by E Middleton, Jr., CE Reed, EF Ellis, et al. St. Louis, MO, Mosby Year Book, Inc., 1998

2. Girard M, Lacasse Y, Cormier Y: Hypersensitivity pneumonitis. Allergy 2009;64:322-334

3. Grunes D, Beasley MB: Hypersensitivity pneumonitis: A review and update of histologic findings. J Clin Pathol 2013;66:888-895

Day(s) and Time(s) Performed

Monday through Friday

Analytic Time

Same day/1 day

CPT Code Information

86606

86609 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HYPS Hypersensitivity Pneum Panel, IgG,S In Process

 

Result ID Test Result Name Result LOINC Value
MPSF Micropolyspora faeni, IgG Ab, S 26948-0
SASP Aspergillus fumigatus, IgG Ab, S 26954-8
TAMV Thermoactinomyces vulgaris, IgG Ab 34190-9