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Test ID LAA Lactate, Plasma

Reporting Name

Lactate, P

Useful For

Diagnosing and monitoring patients with lactic acidosis

Specimen Type

Plasma NaFl-KOx


Specimen Required


Collection Container/Tube: Grey top (potassium oxalate/sodium fluoride)

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions:

1. Collection must be at least 1 mL in a 2-mL draw tube or at least 2 mL in a 4-mL draw tube.

2. Spin down and separate plasma from cells.

Additional Information: Patient's age and sex is required.


Specimen Minimum Volume

0.2 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma NaFl-KOx Frozen 30 days

Reference Values

≤2 years: 0.6-3.2 mmol/L

>2 years: 0.6-2.3 mmol/L

Day(s) and Time(s) Performed

Monday through Sunday; Continuously

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

83605

LOINC Code Information

Test ID Test Order Name Order LOINC Value
LAA Lactate, P 2524-7

 

Result ID Test Result Name Result LOINC Value
LAA Lactate, P 2524-7

Clinical Information

Lactate is the end product of anaerobic carbohydrate metabolism. Major sites of production are skeletal muscle, brain, and erythrocytes. Lactate is metabolized by the liver. The concentration of lactate depends on the rate of production and the rate of liver clearance. The liver can adequately clear lactate until the concentration reaches approximately 2 mmol/L. When this level is exceeded, lactate begins to accumulate rapidly. For example, while resting lactate levels are usually <1 mmol/L, during strenuous exercise levels can rise >20 mmol/L within a few seconds.

 

Lactic acidosis signals the deterioration of the cellular oxidative process and is associated with hyperpnea, weakness, fatigue, stupor, and finally coma. These conditions may be irreversible, even after treatment is administered. Lactate acidosis may be associated with hypoxic conditions (eg, shock, hypovolemia, heart failure, pulmonary insufficiency), metabolic disorders (eg, diabetic ketoacidosis, malignancies), and toxin exposures (eg, ethanol, methanol, salicylates).

Interpretation

While no definitive concentration of lactate has been established for the diagnosis of lactic acidosis, lactate concentrations exceeding 5 mmol/L and pH <7.25 are generally considered indicative of significant lactic acidosis.

Clinical Reference

1. Mizock BA: The hepatosplanchnic area and hyperlactatemia: A tale of two lactates. Crit Care Med 2001;29(2):447-449

2. Duke T: Dysoxia and lactate. Arch Dis Child 1999;81(4):343-350

Analytic Time

Same day/1 day

Method Name

Photometric, Lactate Oxidase/Peroxidase (VITROS Dry Slide)