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Test ID MUR Lysozyme (Muramidase), Plasma

Reporting Name

Lysozyme (Muramidase), P

Useful For

Confirming marked increases in the granulocyte or monocyte pools as in granulocytic or monocytic leukemias, myeloproliferative disorders, and malignant histiocytosis

 

Following the course of therapy in cases of chronic granulocytic or chronic monocytic leukemias

Specimen Type

Plasma EDTA


Specimen Required


Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma EDTA Frozen 30 days

Reference Values

≥12 months: 2.7-9.4 mcg/mL

Reference values have not been established for patients who are <12 months of age.

Day(s) and Time(s) Performed

Monday through Friday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

85549

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MUR Lysozyme (Muramidase), P 2589-0

 

Result ID Test Result Name Result LOINC Value
MUR Lysozyme (Muramidase), P 2589-0

Clinical Information

Lysozyme is a bacteriolytic enzyme that is found in some hematopoietic cells. It is primarily present in granulocytes, monocytes, and histiocytes. The enzyme is present in only minute amounts in lymphocytes; and is not present in myeloblasts, eosinophils, and basophils.

 

Lysozyme in the plasma comes chiefly from the degradation of granulocytes and monocytes and its concentration reflects the turnover of these cells. Increases are seen in benign (eg, infection, inflammation) and malignant processes(eg, some leukemias). Plasma lysozyme is elevated in patients with acute or chronic granulocytic or monocytic leukemias and falls with successful treatment. Conversely, patients with lymphocytic leukemia may have depressed plasma lysozyme levels.

 

Patients with renal disorders (including rejection of transplanted kidneys) or Crohn’s disease (regional enteritis) also tend to have elevated levels of plasma lysozyme.

Interpretation

Levels >200 mcg/mL may be seen in acute nonlymphocytic leukemia (M2, M4, M5) or chronic granulocytic leukemias.

Clinical Reference

Catovsky D, Galton DA, Griffin C: The significance of lysozyme estimations in acute myeloid and chronic monocytic leukaemia. Brit J Haematol 1971;21:565-580

Analytic Time

2 days

Method Name

Turbidimetric