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Test ID TAMV Thermoactinomyces vulgaris, IgG Antibodies, Serum

Useful For

Evaluation of patients suspected of having hypersensitivity pneumonitis induced by exposure to Thermoactinomyces vulgaris

Method Name

Fluorescence Enzyme Immunoassay (FEIA)

Reporting Name

Thermoactinomyces vulgaris, IgG Ab

Specimen Type

Serum


Specimen Required


Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.5 mL


Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Clinical Information

Thermoactinomyces vulgaris is one of the causative agents of hypersensitivity pneumonitis (HP). Other causative microorganisms include Micropolyspora faeni and Aspergillus fumigatus. The development of HP caused by Thermoactinomyces vulgaris is accompanied by an immune response to Thermoactinomyces vulgaris antigens with production of IgG antibodies. While the immunopathogenesis of HP is not known, several immune mechanisms are postulated to play a role, including both cellular and humoral mechanisms.(1)

Reference Values

0-12 years: ≤6.6 mg/L

13-18 years: ≤11.0 mg/L

>18 years: ≤23.9 mg/L

Interpretation

Elevated concentrations of IgG antibodies to Thermoactinomyces vulgaris, Aspergillus fumigatus, or Micropolyspora faeni in patients with signs and symptoms of hypersensitivity pneumonitis may be consistent with disease caused by exposure to 1 or more of these organic antigens.

Clinical Reference

1. Fink JN, Zacharisen MC: Chapter 69: Hypersensitivity pneumonitis. In Allergy Principles and Practice. Vol 1. Fifth edition. Edited by E Middleton Jr, CE Reed, EF Ellis, et al. St. Louis, MO, Mosby Year Book Inc., 1998

2. Girard M, Lacasse Y, Cormier Y: Hypersensitivity pneumonitis. Allergy 2009;64:322-334

3. Grunes D, Beasley MB: Hypersensitivity pneumonitis: A review and update of histologic findings. J Clin Pathol 2013;66:888-895

Day(s) and Time(s) Performed

Monday through Friday

Analytic Time

Same day/1 day

Test Classification

This test was developed using an analyte specific reagent. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

86609

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TAMV Thermoactinomyces vulgaris, IgG Ab 34190-9

 

Result ID Test Result Name Result LOINC Value
TAMV Thermoactinomyces vulgaris, IgG Ab 34190-9