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Test ID TLU Thallium, 24 Hour, Urine

Reporting Name

Thallium, 24 Hr, U

Useful For

Detecting toxic thallium exposure in 24-hour urine specimens

Specimen Type

Urine


Necessary Information


24-Hour volume is required.



Specimen Required


Patient Preparation: High concentrations of gadolinium and iodine are known to interfere with most metals tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

Supplies: Urine Tubes, 10 mL (T068)

Collection Container/Tube: Clean, plastic urine container with no metal cap or glued insert

Submission Container/Tube: Plastic, 10-mL urine tube (T068) or a clean, plastic aliquot container with no metal cap or glued insert

Specimen Volume: 10 mL

Collection Instructions:

1. Collect urine for 24 hours.

2. Refrigerate specimen within 4 hours of completion of 24-hour collection.

3. Aliquot 10 mL in a plastic 10-mL urine tube (T068) or a clean, plastic aliquot container with no metal cap or glued insert.

4. See Trace Metals Analysis Specimen Collection and Transport in Special Instructions for complete instructions.

Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens in Special Instructions for multiple collections.


Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reference Values

0-17 years: not established

≥18 years: <2 mcg/24 hour

Day(s) and Time(s) Performed

Tuesday, Friday; 8 a.m.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

83018

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TLU Thallium, 24 Hr, U 5746-3

 

Result ID Test Result Name Result LOINC Value
8603 Thallium, 24 Hr, U 5746-3
TIME2 Collection Duration 13362-9
VL12 Urine Volume 3167-4

Clinical Information

Thallium is found in some depilatories and rodenticides. Accidental ingestion may lead to vomiting, diarrhea, and leg pains followed by a severe and sometimes fatal sensorimotor polyneuropathy and renal failure. Alopecia (hair loss) may occur 3 weeks after poisoning. The fatal dose is approximately 1 g.

Interpretation

Normal daily output is less than 1 mcg/day.

 

Exposed patients can have urine output greater than 10 mcg/day. The long-term consequences of such an exposure are poor.

Clinical Reference

1. Bank WJ, Pleasure DE, Suzuki K, et al: Thallium poisoning. Arch Neurol 1972;26:456-464

2. Pelclova D, Urban P, Ridson P, et al: Two-year follow-up of two patients after severe thallium intoxication. Hum Exp Toxicol. 2009 May;28(5):263-272

3. Zhao G, Ding M, Zhang B, et al: Clinical manifestations and management of acute thallium poisoning. Eur Neurol 2008;60(6):292-297

Analytic Time

1 day

Method Name

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

Urine Preservative Collection Options

Ambient

Yes

Refrigerated

Preferred

Frozen

Yes

6N HCl

Yes

50% Acetic Acid

Yes

Na2CO3

No

Toluene

Yes

6N HNO3

Yes

Boric Acid

No

Thymol

No