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Test ID CVRMA Cardiovascular Risk Marker Panel, Serum


Specimen Required


Patient Preparation:

1. Patients must be fasting for at least 12 to 14 hours.

2. Patient must not consume any alcohol for 24 hours before specimen collection.

Collection Container/Tube: 

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 2.5 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial. Send refrigerated.


Useful For

Assessment for risk of developing cardiovascular disease, major adverse cardiovascular events, or ischemic cerebrovascular events

Profile Information

Test ID Reporting Name Available Separately Always Performed
NHDCH Non HDL Cholesterol No Yes
CLDL Calculated LDL No Yes
HDCH Cholesterol, HDL, S Yes Yes
CHOL Cholesterol, Total, S Yes Yes
TRIG Triglycerides, S Yes Yes
CVINT Interpretation No Yes
LIPA1 Lipoprotein(a), S Yes Yes
HSCRP C-Reactive Protein, High Sens, S Yes Yes
APOLB Apolipoprotein B, S Yes Yes

Method Name

LIPA1, HSCRP, APOLB: Immunoturbidimetry

CHOL, TRIG, HDCH: Enzymatic Colorimetric

CLDL: Friedewald Equation

NHDCH: Calculation

Reporting Name

Cardiovascular Risk Marker Panel, S

Specimen Type

Serum

Specimen Minimum Volume

1.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
  Frozen  30 days

Clinical Information

Cardiovascular disease remains the leading cause of morbidity and mortality despite well-defined risk factors and treatment strategies. Atherosclerosis, the underlying cause of cardiovascular disease, is a buildup of plaque within arteries. This buildup of plaque can lead to chronic or acute restrictions in blood flow resulting in heart attacks and strokes. Many of these events occur in individuals with no prior symptoms. Standard risk factors include age, smoking status, hypertension, diabetes, total serum cholesterol, and high-density lipoprotein cholesterol.

 

Apolipoprotein B (ApoB), high-sensitivity C-reactive protein (hsCRP), and lipoprotein (a) (Lp[a]) are serological risk factors endorsed by multiple international guidelines for use in cardiovascular disease risk assessment. Several recent guidelines have suggested that clinicians utilize ApoB, hsCRP, and Lp(a) in selected persons to augment risk classification, guide intensity of risk-reduction therapy and modulate clinical judgment when making therapeutic decision.(1-3)

Reference Values

Age

2-17 years

≥18 years

Non-HDL cholesterol (mg/dL)

**

Acceptable: <120

Borderline high: 120-144

High: ≥145

*

Desirable: <130 mg/dL

Above Desirable: 130-159 mg/dL

Borderline high: 160-189 mg/dL

High: 190-219 mg/dL

Very high: ≥220 mg/dL

LDL cholesterol (mg/dL)

**

Acceptable: <110

Borderline high: 110-129

High: ≥130

***

Desirable: <100

Above Desirable: 100-129

Borderline high: 130-159

High: 160-189

Very high: ≥190

HDL cholesterol (mg/dL)

**

Low: <40

Borderline low: 40-45

Acceptable: > 45

***

Males: ≥40

Females: ≥50

 

Total cholesterol (mg/dL)

**

Acceptable: <170

Borderline high: 170-199

High: ≥200

*

Desirable: < 200

Borderline high: 200 - 239

High: ≥ 240

LIPOPROTEIN (a) (nmol/L)

Not established

< 75 nmol/L

Values ≥ 75 nmol/L may suggest increased risk of coronary heart disease.

C-REACTIVE PROTEIN HIGH SENSITIVITY

*

Lower risk: <2.0 mg/L

Higher risk: ≥2.0 mg/L

Acute inflammation: >10.0 mg/L

*

Lower risk: <2.0 mg/L

Higher risk: ≥2.0 mg/L

Acute inflammation: >10.0 mg/L

Apolipoprotein B (mg/dL)

Acceptable: <90

Borderline high: 90-109

High: ≥110

Desirable: <90

Above Desirable: 90-99

Borderline high: 100-119

High: 120-139

Very high: ≥140

 

Age

2-9 years

10-17 years

≥18 years

Triglycerides (mg/dL)

**

Acceptable: <75 

Borderline high: 75-99

High: ≥100

**

Acceptable: <90 

Borderline high: 90-129

High: ≥130

*

Normal: <150

Borderline high: 150-199

High: 200-499

Very high: ≥500

 

*National Lipid Association 2014

**Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents

***National Cholesterol Education Program (NCEP)

Interpretation

Specific interpretations are provided based on lipid results according to Mayo Clinic care process models. Mayo Clinic has adopted the National Lipid Association classifications, which are included as reference values on Mayo Clinic and Mayo Clinic Laboratories reports (see Reference Values).

 

More aggressive treatment strategies may be pursued in patients determined to be at increased risk.

Clinical Reference

1. Jacobson TA, Ito MK, Maki KC, et al: National Lipid Association recommendations for patient-centered management of dyslipidemia: part 1 - executive summary. J Clin Lipidol. 2014 Sep-Oct;8(5):473-488

2. Perk J, DeBacker G, Gohlke H, et al: European Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2012;33:1635-1701

3. Grundy SM, Stone NJ, Bailey AL, et al: 2018. AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019 Jun 18;139(25):e1082-e1143

4. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents; National Heart, Lung, and Blood Institute: Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents. Pediatrics. 2011;128;S213-S256

Day(s) Performed

Monday through Sunday

Report Available

1 to 2 days

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80061-Lipid panel (includes: HDL [CPT Code 83718], total cholesterol [CPT Code 82465], and triglycerides [CPT Code 84478])

83695-Lipoprotein (a)

86141-C-reactive protein; high sensitivity (hsCRP)

82172-Apolipoprotein B

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CVRMA Cardiovascular Risk Marker Panel, S In Process

 

Result ID Test Result Name Result LOINC Value
CVINT Interpretation 59462-2
APOLB Apolipoprotein B, S 1884-6
LIPA1 Lipoprotein(a), S 43583-4
CHOL Cholesterol, Total, S 2093-3
CLDL Calculated LDL 13457-7
HDCH Cholesterol, HDL, S 2085-9
HSCRP C-Reactive Protein, High Sens, S 30522-7
NHDCH Non HDL Cholesterol 43396-1
TRIG Triglycerides, S 2571-8