Test ID GPI Glucose Phosphate Isomerase, Erythrocytes
Reporting Name
Glucose Phosphate Isomerase, BUseful For
A second-order test in the evaluation of individuals with chronic hemolysis
Specimen Type
Whole Blood ACD-BSpecimen Required
Container/Tube:
Preferred: Yellow top (ACD solution B)
Acceptable: EDTA
Specimen Volume: 6 mL
Collection Instructions: Do not transfer blood to other containers.
Specimen Minimum Volume
1 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Whole Blood ACD-B | Refrigerated | 20 days |
Reference Values
≥12 months: 39.3-57.7 U/g Hb
Reference values have not been established for patients who are <12 months of age.
Day(s) and Time(s) Performed
Monday through Friday
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.CPT Code Information
84087
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
GPI | Glucose Phosphate Isomerase, B | 44050-3 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
GPI_ | Glucose Phosphate Isomerase, B | 44050-3 |
Clinical Information
Erythrocyte glucose phosphate isomerase (GPI) deficiency has been reported as a cause of chronic hemolysis in numerous cases. Inheritance is autosomal recessive. Hemolytic disease of the newborn is a common presenting manifestation of GPI deficiency.
Interpretation
Glucose phosphate isomerase (GPI) deficiency causes a moderately severe anemia. GPI values can be 25% of normal.
Increased GPI activity may be seen when young red blood cells are being produced in response to the anemia (reticulocytosis) or in the case of a newborn.
Clinical Reference
Fairbanks VF, Klee GG: Biochemical aspects of hematology. In Tietz Textbook of Clinical Chemistry. Third Edition. Edited by CA Burtis, ER Ashwood, Philadelphia, WB Saunders Company, 1999, pp 1642-1646
Analytic Time
3 daysMethod Name
Kinetic Spectrophotometry (KS)
Forms
If not ordering electronically, complete, print, and send a Benign Hematology Test Request Form (T755) with the specimen.