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Test ID NACCL Sodium, Serum

Reporting Name

Sodium, S

Useful For

Sodium assays are important in assessing acid-base balance, water balance, water intoxication, and dehydration.

Specimen Type


Necessary Information

Patient's age and sex are required.

Specimen Required


Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.5 mL

Collection Instructions:

1. Serum gel tubes should be centrifuged within 2 hours of collection.

2. Red-top tubes should be centrifuged and aliquoted within 2 hours of collection.

Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Ambient  14 days

Reference Values

≥12 months: 135-145 mmol/L

Reference values have not been established for patients that are less than 12 months of age.

Day(s) and Time(s) Performed

Monday through Sunday; Continuously

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
NACCL Sodium, S 2951-2


Result ID Test Result Name Result LOINC Value
NACCL Sodium, S 2951-2

Clinical Information

Sodium is the primary extracellular cation. Sodium is responsible for almost one half the osmolality of the plasma and therefore plays a central role in maintaining the normal distribution of water and the osmotic pressure in the extracellular fluid compartment. The amount of sodium in the body is a reflection of the balance between sodium intake and output.


Hyponatremia (low sodium) is a predictable consequence of decreased intake of sodium, particularly that precipitated or complicated by unusual losses of sodium from the gastrointestinal tract (eg, vomiting and diarrhea), kidneys or sweat glands. Renal loss may be caused by inappropriate choice, dose or use of diuretics; by primary or secondary deficiency of aldosterone and other mineralocorticoids; or by severe polyuria. It is common in metabolic acidosis. Hyponatremia also occurs in nephrotic syndrome, hypoproteinemia, primary and secondary adrenocortical insufficiency and congestive heart failure. Symptoms of hyponatremia are a result of brain swelling and range from weakness to seizures, coma and death.


Hypernatremia (high sodium) is often attributable to excessive loss of sodium-poor body fluids. Hypernatremia is often associated with hypercalcemia and hypokalemia and is seen in liver disease, cardiac failure, pregnancy, burns, and osmotic diuresis. Other causes include decreased production of ADH or decreased tubular sensitivity to the hormone (ie, diabetes insipidus), inappropriate forms of parenteral therapy with saline solutions, or high salt intake without corresponding intake of water. Hypernatremia occurs in dehydration, increased renal sodium conservation in hyperaldosternism, Cushing's syndrome, and diabetic acidosis. Severe hypernatremia may be associated with volume contraction, lactic acidosis and increased hematocrit. Symptoms of hypernatremia range from thirst to confusion, irritability, seizures, coma and death.


Symptoms of hyponatremia depend primarily upon the rate of change in sodium concentration, rather than the absolute level. Typically, sodium values <120 mEq/L result in weakness; values <100 mEq/L in bulbar or pseudobulbar palsy; and values between 90 and 105 mEq/L in severe signs and symptoms of neurological impairment.


Symptoms associated with hypernatremia depend upon the degree of hyperosmolality present.

Clinical Reference

Tietz Textbook of Clinical Chemistry. Edited by CA Burtis, ER Ashwood. WB Saunders Company. Philadelphia, PA, 1994

Analytic Time

Same day/1 day

Method Name

Potentiometric/Indirect Ion-Selective Electrode

Also available as part of an Electrolyte Panel.


If not ordering electronically, complete, print, and send a Cardiovascular Test Request Form (T724) with the specimen (