Test ID TLCRU Thallium/Creatinine Ratio, Random, Urine
Reporting Name
Thallium/Creat Ratio, Random, UUseful For
Detecting toxic thallium exposure in random urine specimens
Profile Information
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
TLCR | Thallium/Creat Ratio, U | No | Yes |
CDCR | Creatinine Conc | No | Yes |
Specimen Type
UrineSpecimen Required
Patient Preparation: High concentrations of gadolinium and iodine are known to interfere with most metals tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Supplies: Urine Tubes, 10 mL (T068)
Collection Container/Tube: Clean, plastic urine collection container with no metal cap or glued insert
Submission Container/Tube: Plastic, 10-mL urine tube (T068) or a clean, plastic aliquot container with no metal cap or glued insert
Specimen Volume: 2 mL
Collection Instructions:
1. Collect a random urine specimen.
2. See Trace Metals Analysis Specimen Collection and Transport in Special Instructions for complete instructions.
Specimen Minimum Volume
1.3 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Urine | Refrigerated (preferred) | 28 days | |
Ambient | 28 days | ||
Frozen | 28 days |
Special Instructions
Reference Values
0-17 years: not established
≥18 years: <2 mcg/g creatinine
Day(s) and Time(s) Performed
Tuesday, Friday; 8 a.m.
Test Classification
See Individual Test IDsCPT Code Information
83018 Thallium concentration
82570 Creatinine concentration
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
TLCRU | Thallium/Creat Ratio, Random, U | 13469-2 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
CDCR | Creatinine Conc | 2161-8 |
32870 | Thallium/Creat Ratio, U | 13469-2 |
Clinical Information
Thallium is found in some depilatories and rodenticides. Accidental ingestion may lead to vomiting, diarrhea, and leg pains followed by a severe and sometimes fatal sensorimotor polyneuropathy. Alopecia (hair loss) may occur 3 weeks after poisoning. The fatal dose is approximately 1 gram.
Interpretation
Patients exposed to high doses of thallium (>1 g) present with alopecia, peripheral neuropathy and seizures, and renal failure.
Normal daily output is less than 1 mcg/day.
Exposed patients can have urine output greater than 10 mcg/day. The long-term consequences of such an exposure are poor.
Clinical Reference
1. Bank WJ, Pleasure DE, Suzuki K, et al: Thallium poisoning. Arch Neurol 1972;26:456-464
2. Pelclova D, Urban P, Ridson P, et al: Two-year follow-up of two patients after severe thallium intoxication. Hum Exp Toxicol 2009 May;28(5):263-272
3. Zhao G, Ding M, Zhang B, et al: Clinical manifestations and management of acute thallium poisoning. Eur Neurol 2008;60(6):292-297
Analytic Time
1 dayMethod Name
TLCR: Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)
CDCR: Enzymatic Colorimetric Assay