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Test ID ABYSR Antibody Screen with Reflexed Antibody Identification, RBC

Shipping Instructions

Specimen must arrive within 72 hours of draw.

Specimen Required

Container/Tube: Pink (EDTA)

Specimen Volume: 6 mL

Collection Instructions: Send specimen in original tube.

Useful For

Detection of allo- or autoantibodies directed against red blood cell antigens in the settings of pretransfusion testing


Evaluation of transfusion reactions


Evaluation of hemolytic anemia

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
ABIDR Antibody Identification, RBC Yes No
ABTIR Antibody Titer, RBC Yes No

Testing Algorithm

If the antibody screen is positive, then antibody identification will be performed.

If the patient has a history of antibodies that are still detected, the antibody screen will be canceled and replaced by the antibody identification.

If certain antibodies are detected and the patient is known to be pregnant, an antibody titration will be performed.

Method Name


Reporting Name

Antibody Screen, RBC

Specimen Type

Whole Blood EDTA

Specimen Minimum Volume

3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole Blood EDTA Refrigerated (preferred) 4 days
  Ambient  4 days

Clinical Information

Transfusion and pregnancy are the primary means of sensitization to red cell antigens. In a given population, 2% to 4% of the general population possess irregular red cell alloantibodies. Such antibodies may cause hemolytic disease of the newborn or hemolysis of transfused donor red blood cells.

Reference Values


If positive, antibody identification will be performed.


A positive result (antibody detected) necessitates antibody identification to establish the specificity and clinical significance of the antibody detected.


Alloantibodies detected on pregnant Mayo Clinic-Rochester patients will be evaluated for the allo-antibody titer. If antibody reacts strongly, the titre test will be performed.


Negative results indicate no antibody was detected.

Clinical Reference

AABB Technical Manual. 19th edition. Edited by MK Fung, AF Eder, SL Spitalnik, CM Westhoff: AABB 2017

Test Classification

This test has been cleared, approved or is exempt by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
ABYSR Antibody Screen, RBC 890-4


Result ID Test Result Name Result LOINC Value
ABYSR Antibody Screen, RBC 890-4


If not ordering electronically, complete, print, and send a Benign Hematology Test Request Form (T755) with the specimen.

Day(s) Performed

Monday through Sunday

Report Available

Same day/1 to 2 days