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Test ID AGU20 Acylglycines, Quantitative, Random, Urine


Advisory Information


Diagnostic specificity of inborn errors of metabolism via urine acylglycine testing is available only for selected inborn errors of metabolism; it is recommended that urine organic acids (OAU / Organic Acids Screen, Urine) be ordered and assessed simultaneously due to the limited number of metabolites included in this urine acylglycine test.



Necessary Information


1. Patient's age and gender are required.

2. Include family history, clinical condition (asymptomatic or acute episode), diet, and drug therapy information.



Specimen Required


Supplies: Urine Tubes, 10 mL (T068)

Container/Tube: Plastic, 10-mL urine tube

Specimen Volume: 10 mL

Pediatric: If insufficient collection volume, submit as much specimen as possible in a single container; the laboratory will determine if volume is sufficient for testing.

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.


Forms

Biochemical Genetics Patient Information (T602) in Special Instructions.

Useful For

Diagnosis and monitoring for patients affected with 1 of the following inborn errors of metabolism:

Fatty Acid Oxidation Disorders

-Glutaric acidemia type II

-Medium-chain 3-ketoacyl-CoA thiolase (MCKAT) deficiency

-Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency

-Short chain acyl-CoA dehydrogenase (SCAD) deficiency

 

Organic Acidurias

-2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (2M3HBD) deficiency

-2-Methylbutyryl-CoA dehydrogenase deficiency

-3-Methylcrotonyl-CoA carboxylase deficiency

-3-Methylglutaconyl-CoA-hydratase deficiency

-Aminoacylase 1 deficiency

-Beta-ketothiolase deficiency

-Ethylmalonic encephalopathy

-Glutaryl-CoA dehydrogenase deficiency

-Isobutyryl-CoA dehydrogenase (IBD) deficiency

-Isovaleryl-CoA dehydrogenase deficiency

-Multiple carboxylase deficiency

-Propionic acidemia

Method Name

Gas Chromatography-Mass Spectrometry (GC-MS) Stable Isotope Dilution Analysis

Reporting Name

Acylglycines, QN, U

Specimen Type

Urine

Specimen Minimum Volume

4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Frozen (preferred) 416 days
  Refrigerated  9 days

Clinical Information

Acylglycines are glycine conjugates of acyl-CoA species, which occur as normal intermediates of amino acid and fatty acid metabolism. In abnormal concentrations, acylglycines are biochemical markers of selected inborn errors of metabolism (IEM). Analysis of acylglycines is useful for the diagnosis and monitoring for specific fatty acid oxidation disorders and organic acidurias, although is recommended to use this testing in conjunction with urine organic acids and plasma acylcarnitines testing in order to establish a diagnosis.

 

In particular, acylglycine analysis is more sensitive and specific for the identification of asymptomatic patients and those who may experience mild or intermittent biochemical phenotypes that could be missed by organic acid analysis alone.

Reference Values

Reference Values; Expressed as mg/g creatinine

 

≤11 Months

12-23 Months

24-35 Months

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.18-1.30

0.18-1.30

0.17-1.29

0.17-1.29

0.17-1.28

0.17-1.28

n-Propionylglycine

0.16-0.91

0.16-0.91

0.16-0.91

0.16-0.91

0.16-0.90

0.16-0.90

Isobutyrylglycine

0.17-2.50

0.17-2.50

0.17-2.49

0.17-2.49

0.17-2.47

0.17-2.47

Ethylmalonic acid

2.18-15.29

2.06-17.30

2.15-15.13

2.03-17.08

2.11-14.94

2.00-16.82

n-Butyrylglycine

0.20-1.37

0.19-1.29

0.20-1.36

0.19-1.28

0.20-1.34

0.19-1.26

2-Methylsuccinic acid

1.16-5.97

1.09-6.10

1.14-5.89

1.07-6.01

1.13-5.79

1.05-5.91

2-Methylbutyrylglycine

0.10-1.42

0.09-1.40

0.10-1.40

0.09-1.39

0.10-1.38

0.09-1.37

Isovalerylglycine

0.47-7.15

0.47-7.15

0.48-7.13

0.48-7.13

0.48-7.10

0.48-7.10

Glutaric acid

0.45-6.20

0.47-6.02

0.45-6.11

0.46-5.92

0.44-6.00

0.46-5.81

3-Methylcrotonylglycine

0.28-1.55

0.28-1.55

0.28-1.53

0.28-1.53

0.28-1.50

0.28-1.50

n-Tiglylglycine

1.05-5.76

1.05-5.76

1.05-5.67

1.05-5.67

1.05-5.56

1.05-5.56

3-Methylglutaconic acid

2.79-12.73

2.79-12.73

2.77-12.60

2.77-12.60

2.75-12.43

2.75-12.43

n-Hexanoylglycine

0.35-1.70

0.36-1.67

0.35-1.69

0.36-1.66

0.35-1.68

0.35-1.65

n-Octanoylglycine

0.16-1.60

0.16-1.60

0.16-1.59

0.16-1.59

0.16-1.58

0.16-1.58

3-Phenylpropionylglycine

0.08-1.10

0.07-1.06

0.08-1.09

0.07-1.05

0.08-1.09

0.07-1.05

trans-Cinnamoylglycine

0.41-4.81

0.40-4.73

0.41-4.81

0.40-4.73

0.41-4.81

0.40-4.73

Suberylglycine

0.38-3.09

0.38-3.09

0.38-3.05

0.38-3.05

0.37-3.01

0.37-3.01

Dodecanedioic acid

0.01-0.09

0.01-0.09

0.01-0.09

0.01-0.09

0.01-0.09

0.01-0.09

Tetradecanedioic acid

0.01-0.07

0.01-0.07

0.01-0.07

0.01-0.07

0.01-0.06

0.01-0.06

Hexadecanedioic acid

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

 

 

3 Years

4 Years

5 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.17-1.26

0.17-1.26

0.17-1.24

0.17-1.24

0.17-1.21

0.17 - 1.21

n-Propionylglycine

0.16-0.89

0.16-0.89

0.16-0.88

0.16-0.88

0.16-0.87

0.16-0.87

Isobutyrylglycine

0.17-2.46

0.17-2.46

0.17-2.43

0.17-2.43

0.17-2.39

0.17-2.39

Ethylmalonic acid

2.08-14.72

1.97-16.53

2.01-14.31

1.91-16.00

1.94-13.85

1.84-15.41

n-Butyrylglycine

0.20-1.32

0.19-1.24

0.20-1.29

0.19-1.21

0.19-1.25

0.19-1.18

2-Methylsuccinic acid

1.10-5.69

1.03-5.80

1.06-5.50

0.99-5.59

1.02-5.28

0.95-5.35

2-Methylbutyrylglycine

0.10-1.36

0.08-1.36

0.10-1.32

0.08-1.32

0.10-1.28

0.08-1.29

Isovalerylglycine

0.48-7.07

0.48-7.07

0.49-7.00

0.49-7.00

0.50-6.92

0.50-6.92

Glutaric acid

0.43-5.88

0.45-5.68

0.42-5.65

0.44-5.44

0.41-5.39

0.43-5.17

3-Methylcrotonylglycine

0.28-1.47

0.28-1.47

0.28-1.42

0.28-1.42

0.28-1.35

0.28-1.35

n-Tiglylglycine

1.05-5.44

1.05-5.44

1.04-5.22

1.04-5.22

1.03-4.98

1.03-4.98

3-Methylglutaconic acid

2.72-12.25

2.72-12.25

2.68-11.90

2.68-11.90

2.62-11.50

2.62-11.50

n-Hexanoylglycine

0.34-1.66

0.35-1.64

0.34-1.64

0.34-1.61

0.33-1.62

0.34-1.59

n-Octanoylglycine

0.16-1.57

0.16-1.57

0.16-1.55

0.16-1.55

0.16-1.53

0.16-1.53

3-Phenylpropionylglycine

0.08-1.08

0.08-1.04

0.08-1.07

0.08-1.04

0.08-1.06

0.08-1.03

trans-Cinnamoylglycine

0.42-4.80

0.40-4.73

0.42-4.80

0.40-4.73

0.42-4.78

0.40-4.72

Suberylglycine

0.37-2.97

0.37-2.97

0.36-2.90

0.36-2.90

0.35-2.82

0.35-2.82

Dodecanedioic acid

0.01-0.09

0.01-0.09

0.01-0.09

0.01-0.09

0.01-0.08

0.01-0.08

Tetradecanedioic acid

0.01-0.06

0.01-0.06

0.01-0.06

0.01-0.06

0.01-0.06

0.01-0.06

Hexadecanedioic acid

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

 

 

6 Years

7 Years

8 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.16-1.18

0.16-1.18

0.16-1.15

0.16-1.15

0.15-1.12

0.15-1.12

n-Propionylglycine

0.16-0.85

0.16-0.85

0.15-0.83

0.15-0.83

0.15-0.81

0.15-0.81

Isobutyrylglycine

0.17-2.35

0.17-2.35

0.17-2.31

0.17-2.30

0.17-2.26

0.16-2.25

Ethylmalonic acid

1.86-13.33

1.76-14.76

1.77-12.77

1.68-14.07

1.69-12.18

1.61-13.39

n-Butyrylglycine

0.19-1.21

0.19-1.14

0.19-1.17

0.18-1.10

0.19-1.14

0.18-1.06

2-Methylsuccinic acid

0.97-5.05

0.90-5.09

0.92-4.80

0.85-4.80

0.86-4.56

0.80-4.52

2-Methylbutyrylglycine

0.10-1.23

0.08-1.25

0.09-1.19

0.08-1.21

0.09-1.14

0.08-1.16

Isovalerylglycine

0.51-6.82

0.51-6.82

0.51-6.69

0.51-6.69

0.52-6.55

0.52-6.55

Glutaric acid

0.40-5.10

0.42-4.87

0.39-4.79

0.40-4.54

0.37-4.47

0.39-4.21

3-Methylcrotonylglycine

0.28-1.29

0.28-1.29

0.27-1.22

0.27-1.22

0.27-1.16

0.27-1.16

n-Tiglylglycine

1.01-4.73

1.01-4.73

0.99-4.46

0.99-4.46

0.96-4.22

0.96-4.22

3-Methylglutaconic acid

2.55-11.05

2.55-11.05

2.48-10.55

2.48-10.55

2.40-10.05

2.40-10.05

n-Hexanoylglycine

0.33-1.59

0.33-1.56

0.32-1.56

0.32-1.53

0.31-1.53

0.31-1.50

n-Octanoylglycine

0.16-1.51

0.16-1.51

0.15-1.49

0.15-1.49

0.15-1.47

0.15-1.47

3-Phenylpropionylglycine

0.08-1.04

0.08-1.02

0.08-1.03

0.08-1.01

0.08-1.02

0.08-1.00

trans-Cinnamoylglycine

0.43-4.76

0.40-4.71

0.43-4.74

0.40-4.69

0.43-4.71

0.40-4.65

Suberylglycine

0.34-2.74

0.34-2.74

0.32-2.66

0.32-2.66

0.31-2.58

0.31-2.58

Dodecanedioic acid

0.01-0.08

0.01-0.08

0.01-0.08

0.01-0.08

0.01-0.08

0.01-0.08

Tetradecanedioic acid

0.01-0.06

0.01-0.06

0.01-0.06

0.01-0.06

0.01-0.05

0.01-0.05

Hexadecanedioic acid

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.03

0.01-0.03

 

 

9 Years

10 Years

11 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.15-1.09

0.15-1.09

0.15-1.07

0.15 1.07

0.14-1.04

0.14-1.04

n-Propionylglycine

0.14-0.79

0.14-0.79

0.13-0.77

0.13-0.77

0.13-0.76

0.13-0.76

Isobutyrylglycine

0.17-2.21

0.16-2.20

0.17-2.16

0.16-2.15

0.17-2.11

0.16-2.10

Ethylmalonic acid

1.62-11.59

1.53-12.73

1.55-11.00

1.47-12.10

1.49-10.43

1.41-11.52

n-Butyrylglycine

0.18-1.10

0.18-1.03

0.18-1.07

0.18-0.99

0.18-1.05

0.17-0.96

2-Methylsuccinic acid

0.81-4.32

0.75-4.24

0.76-4.10

0.71-3.98

0.71-3.90

0.67-3.75

2-Methylbutyrylglycine

0.09-1.09

0.08-1.13

0.09-1.05

0.08-1.09

0.09-1.01

0.08-1.06

Isovalerylglycine

0.52-6.40

0.52-6.40

0.53-6.24

0.53-6.24

0.53-6.07

0.53-6.07

Glutaric acid

0.36-4.16

0.37-3.88

0.36-3.87

0.36-3.57

0.35-3.60

0.35-3.28

3-Methylcrotonylglycine

0.26-1.10

0.26-1.10

0.25-1.04

0.25-1.04

0.24-1.00

0.24-1.00

n-Tiglylglycine

0.93-4.00

0.93-4.00

0.90-3.80

0.90-3.80

0.87-3.64

0.87-3.64

3-Methylglutaconic acid

2.32-9.54

2.32-9.54

2.23-9.07

2.23-9.07

2.15-8.63

2.15-8.63

n-Hexanoylglycine

0.30-1.50

0.30-1.46

0.29-1.47

0.29-1.43

0.29-1.45

0.28-1.39

n-Octanoylglycine

0.15-1.45

0.15-1.45

0.15-1.44

0.15-1.44

0.15-1.42

0.15-1.42

3-Phenylpropionylglycine

0.08-1.00

0.08-1.00

0.08-1.00

0.09-0.99

0.08-0.99

0.09-0.98

trans-Cinnamoylglycine

0.43-4.67

0.40-4.60

0.42-4.63

0.40-4.54

0.42-4.59

0.39-4.46

Suberylglycine

0.30-2.52

0.30-2.52

0.29-2.46

0.29-2.46

0.28-2.42

0.28-2.42

Dodecanedioic acid

0.01-0.08

0.01-0.08

0.01-0.08

0.01-0.08

0.01-0.08

0.01-0.08

Tetradecanedioic acid

0.01-0.05

0.01-0.05

0.01-0.05

0.01-0.05

0.01-0.05

0.01-0.05

Hexadecanedioic acid

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

 

 

12 Years

13 Years

14 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.14-1.01

0.14-1.01

0.14-0.98

0.14-0.98

0.13-0.95

0.13-0.95

n-Propionylglycine

0.13-0.74

0.13-0.74

0.12-0.72

0.12-0.72

0.12-0.71

0.12-0.71

Isobutyrylglycine

0.17-2.05

0.16-2.05

0.17-2.00

0.16-2.01

0.17-1.95

0.16-1.97

Ethylmalonic acid

1.44-9.88

1.36-10.99

1.40-9.36

1.31-10.50

1.37-8.88

1.28-10.04

n-Butyrylglycine

0.18-1.03

0.17-0.93

0.18-1.01

0.17-0.90

0.18-1.00

0.17-0.88

2-Methylsuccinic acid

0.67-3.71

0.63-3.54

0.64-3.53

0.60-3.35

0.61-3.37

0.58-3.19

2-Methylbutyrylglycine

0.09-0.98

0.08-1.03

0.09-0.95

0.08-1.01

0.09-0.93

0.08-0.99

Isovalerylglycine

0.53-5.90

0.53-5.90

0.53-5.73

0.53-5.73

0.53-5.56

0.53-5.56

Glutaric acid

0.35-3.35

0.35-3.00

0.34-3.13

0.34-2.75

0.34-2.94

0.34-2.53

3-Methylcrotonylglycine

0.24-0.96

0.24-0.96

0.23-0.93

0.23-0.93

0.23-0.91

0.23-0.91

n-Tiglylglycine

0.84-3.51

0.84-3.51

0.82-3.40

0.82-3.40

0.80-3.30

0.80-3.30

3-Methylglutaconic acid

2.07-8.25

2.07-8.25

2.01-7.93

2.01-7.93

1.95-7.67

1.95-7.67

n-Hexanoylglycine

0.28-1.43

0.27-1.36

0.27-1.41

0.26-1.32

0.27-1.39

0.26-1.28

n-Octanoylglycine

0.15-1.41

0.15-1.41

0.15-1.39

0.15-1.39

0.14-1.38

0.14-1.38

3-Phenylpropionylglycine

0.08-0.98

0.09-0.98

0.08-0.97

0.09-0.97

0.08-0.97

0.09-0.96

trans-Cinnamoylglycine

0.41-4.54

0.39-4.36

0.40-4.49

0.38-4.26

0.39-4.44

0.38-4.14

Suberylglycine

0.28-2.38

0.28-2.38

0.27-2.35

0.27-2.35

0.27-2.33

0.27-2.33

Dodecanedioic acid

0.01-0.08

0.01-0.08

0.01-0.08

0.01-0.08

0.01-0.07

0.01-0.07

Tetradecanedioic acid

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

Hexadecanedioic acid

0.01-0.03

0.01-0.03

 0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

 

 

15 Years

16 Years

17 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.13-0.92

0.13-0.92

0.14-0.89

0.14-0.89

0.14-0.87

0.14-0.87

n-Propionylglycine

0.13-0.70

0.13-0.70

0.13-0.69

0.13-0.69

0.13-0.69

0.13-0.69

Isobutyrylglycine

0.18-1.90

0.16-1.93

0.18-1.85

0.16-1.89

0.18-1.81

0.17-1.85

Ethylmalonic acid

1.35-8.44

1.25-9.61

1.33-8.05

1.23-9.20

1.32-7.72

1.22-8.79

n-Butyrylglycine

0.18-0.99

0.17-0.86

0.18-0.98

0.17-0.84

0.19-0.97

0.17-0.82

2-Methylsuccinic acid

0.58-3.22

0.56-3.05

0.56-3.08

0.55-2.92

0.55-2.96

0.54-2.81

2-Methylbutyrylglycine

0.09-0.91

0.08-0.97

0.09-0.90

0.08-0.95

0.09-0.89

0.09-0.94

Isovalerylglycine

0.53-5.39

0.53-5.39

0.53-5.23

0.53-5.23

0.53-5.07

0.53-5.07

Glutaric acid

0.34-2.77

0.34-2.32

0.34-2.63

0.34-2.14

0.34-2.50

0.34-1.98

3-Methylcrotonylglycine

0.23-0.89

0.23-0.89

0.23-0.87

0.23-0.87

0.24-0.86

0.24-0.86

n-Tiglylglycine

0.80-3.22

0.80-3.22

0.80-3.14

0.80-3.14

0.81-3.06

0.81-3.06

3-Methylglutaconic acid

1.91-7.48

1.91-7.48

1.89-7.34

1.89-7.34

1.90-7.25

1.90-7.25

n-Hexanoylglycine

0.26-1.38

0.25-1.24

0.26-1.37

0.26-1.20

0.26-1.35

0.26-1.16

n-Octanoylglycine

0.14-1.37

0.14-1.37

0.15-1.37

0.15-1.37

0.15-1.36

0.15-1.36

3-Phenylpropionylglycine

0.09-0.96

0.10-0.96

0.09-0.96

0.10-0.95

0.09-0.96

0.10-0.94

trans-Cinnamoylglycine

0.39-4.38

0.37-4.01

0.38-4.33

0.37-3.88

0.38-4.28

0.36-3.74

Suberylglycine

0.26-2.31

0.26-2.31

0.26-2.29

0.26-2.29

0.26-2.27

0.26-2.27

Dodecanedioic acid

0.01-0.07

0.01-0.07

0.01-0.07

0.01-0.07

0.01-0.07

0.01-0.07

Tetradecanedioic acid

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.03

0.01-0.03

Hexadecanedioic acid

0.01-0.03

0.01-0.03

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

 

 

18 Years

19 Years

20 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.14-0.85

0.14-0.85

0.14-0.83

0.14-0.83

0.14-0.81

0.14-0.81

n-Propionylglycine

0.14-0.68

0.14-0.68

0.14-0.67

0.14-0.67

0.15-0.67

0.15-0.67

Isobutyrylglycine

0.18-1.77

0.18-1.82

0.19-1.74

0.19-1.78

0.19-1.71

0.19-1.74

Ethylmalonic acid

1.32-7.44

1.22-8.40

1.32-7.22

1.22-8.00

1.32-7.04

1.22-7.60

n-Butyrylglycine

0.19-0.96

0.18-0.80

0.19-0.95

0.18-0.78

0.19-0.94

0.19-0.77

2-Methylsuccinic acid

0.54-2.85

0.53-2.71

0.54-2.75

0.53-2.63

0.53-2.67

0.53-2.55

2-Methylbutyrylglycine

0.09-0.88

0.09-0.93

0.10-0.88

0.09-0.91

0.10-0.87

0.09-0.90

Isovalerylglycine

0.53-4.91

0.53-4.91

0.53-4.76

0.53-4.76

0.54-4.62

0.54-4.62

Glutaric acid

0.34-2.39

0.34-1.83

0.35-2.29

0.35-1.70

0.35-2.20

0.35-1.59

3-Methylcrotonylglycine

0.24-0.85

0.24-0.85

0.25-0.84

0.25-0.84

0.26-0.83

0.26-0.83

n-Tiglylglycine

0.83-2.98

0.83-2.98

0.85-2.90

0.85-2.90

0.87-2.83

0.87-2.83

3-Methylglutaconic acid

1.93-7.19

1.93-7.19

1.99-7.15

1.99-7.15

2.07-7.11

2.07-7.11

n-Hexanoylglycine

0.26-1.34

0.26-1.13

0.26-1.32

0.27-1.09

0.26-1.30

0.28-1.06

n-Octanoylglycine

0.15-1.35

0.15-1.35

0.15-1.35

0.15-1.35

0.15-1.34

0.15-1.34

3-Phenylpropionylglycine

0.09-0.95

0.10-0.93

0.09-0.95

0.11-0.92

0.09-0.95

0.11-0.91

trans-Cinnamoylglycine

0.38-4.24

0.36-3.60

0.38-4.19

0.36-3.45

0.38-4.16

0.36-3.31

Suberylglycine

0.26-2.26

0.26-2.26

0.26-2.24

0.26-2.24

0.26-2.22

0.26-2.22

Dodecanedioic acid

0.01-0.06

0.01-0.06

0.01-0.06

0.01-0.06

0.01-0.06

0.01-0.06

Tetradecanedioic acid

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

Hexadecanedioic acid

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

 

 

21 Years

22 Years

23 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.15-0.80

0.15-0.80

0.15-0.79

0.15-0.79

0.15-0.78

0.15-0.78

n-Propionylglycine

0.16-0.66

0.16-0.66

0.16-0.65

0.16-0.65

0.17-0.64

0.17-0.64

Isobutyrylglycine

0.19-1.69

0.20-1.70

0.19-1.68

0.21-1.66

0.19-1.66

0.22-1.62

Ethylmalonic acid

1.33-6.92

1.23-7.19

1.33-6.84

1.24-6.80

1.34-6.78

1.25-6.41

n-Butyrylglycine

0.20-0.92

0.19-0.75

0.20-0.91

0.19-0.74

0.20-0.90

0.20-0.72

2-Methylsuccinic acid

0.54-2.62

0.53-2.48

0.54-2.58

0.54-2.42

0.55-2.55

0.54-2.37

2-Methylbutyrylglycine

0.10-0.87

0.10-0.88

0.10-0.87

0.10-0.86

0.10-0.86

0.10-0.84

Isovalerylglycine

0.54-4.49

0.54-4.49

0.55-4.37

0.55-4.37

0.56-4.26

0.56-4.26

Glutaric acid

0.35-2.13

0.35-1.49

0.35-2.06

0.36-1.41

0.35-2.00

0.36-1.34

3-Methylcrotonylglycine

0.28-0.83

0.28-0.83

0.29-0.82

0.29-0.82

0.30-0.82

0.30-0.82

n-Tiglylglycine

0.90-2.76

0.90-2.76

0.93-2.70

0.93-2.70

0.95-2.64

0.95-2.64

3-Methylglutaconic acid

2.17-7.07

2.17-7.07

2.29-7.02

2.29-7.02

2.41-6.95

2.41-6.95

n-Hexanoylglycine

0.26-1.29

0.28-1.03

0.26-1.27

0.29-1.00

0.26-1.26

0.29-0.98

n-Octanoylglycine

0.15-1.33

0.15-1.33

0.16-1.32

0.16-1.32

0.16-1.30

0.16-1.30

3-Phenylpropionylglycine

0.10-0.94

0.11-0.89

0.10-0.94

0.12-0.88

0.10-0.94

0.12-0.87

trans-Cinnamoylglycine

0.38-4.13

0.36-3.17

0.39-4.10

0.36-3.02

0.39-4.08

0.37-2.89

Suberylglycine

0.26-2.21

0.26-2.21

0.26-2.19

0.26-2.19

0.26-2.17

0.26-2.17

Dodecanedioic acid

0.01-0.06

0.01-0.06

0.01-0.05

0.01-0.05

0.01-0.05

0.01-0.05

Tetradecanedioic acid

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

Hexadecanedioic acid

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

 

 

24 Years

25 Years

26 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.15-0.77

0.15-0.77

0.15-0.75

0.15-0.75

0.15-0.73

0.15-0.73

n-Propionylglycine

0.17-0.62

0.17-0.62

0.17-0.61

0.17-0.61

0.18-0.59

0.18-0.59

Isobutyrylglycine

0.20-1.65

0.22-1.57

0.20-1.65

0.22-1.52

0.20-1.64

0.23-1.48

Ethylmalonic acid

1.35-6.74

1.25-6.04

1.36-6.72

1.26-5.69

1.37-6.70

1.27-5.38

n-Butyrylglycine

0.20-0.89

0.20-0.71

0.20-0.87

0.20-0.70

0.20-0.86

0.20-0.69

2-Methylsuccinic acid

0.55-2.54

0.55-2.32

0.56-2.54

0.56-2.28

0.57-2.54

0.56-2.24

2-Methylbutyrylglycine

0.10-0.86

0.11-0.82

0.11-0.86

0.11-0.79

0.11-0.85

0.11-0.77

Isovalerylglycine

0.56-4.16

0.56-4.16

0.56-4.08

0.56-4.08

0.56-4.01

0.56-4.01

Glutaric acid

0.35-1.94

0.36-1.28

0.35-1.88

0.36-1.24

0.34-1.83

0.36-1.21

3-Methylcrotonylglycine

0.31-0.81

0.31-0.81

0.31-0.81

0.31-0.81

0.32-0.81

0.32-0.81

n-Tiglylglycine

0.97-2.59

0.97-2.59

0.98-2.55

0.98-2.55

0.99-2.51

0.99-2.51

3-Methylglutaconic acid

2.53-6.88

2.53-6.88

2.63-6.78

2.63-6.78

2.72-6.69

2.72-6.69

n-Hexanoylglycine

0.27-1.24

0.30-0.95

0.27-1.23

0.30-0.94

0.27-1.22

0.30-0.92

n-Octanoylglycine

0.16-1.29

0.16-1.29

0.17-1.28

0.17-1.28

0.17-1.26

0.17-1.26

3-Phenylpropionylglycine

0.10-0.94

0.12-0.86

0.11-0.93

0.13-0.85

0.11-0.93

0.13-0.84

trans-Cinnamoylglycine

0.39-4.07

0.38-2.76

0.39-4.06

0.39-2.64

0.40-4.06

0.39-2.54

Suberylglycine

0.27-2.16

0.27-2.16

0.27-2.14

0.27-2.14

0.27-2.12

0.27-2.12

Dodecanedioic acid

0.01-0.05

0.01-0.05

0.01-0.05

0.01-0.05

0.01-0.05

0.01-0.05

Tetradecanedioic acid

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

Hexadecanedioic acid

0.01-0.02

0.01-0.02

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

 

 

27 Years

28 Years

29 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.15-0.71

0.15-0.71

0.15-0.69

0.15-0.69

0.15-0.67

0.15-0.67

n-Propionylglycine

0.18-0.57

0.18-0.57

0.19-0.56

0.19-0.56

0.19-0.54

0.19-0.54

Isobutyrylglycine

0.20-1.63

0.23-1.44

0.21-1.62

0.23-1.41

0.21-1.61

0.22-1.38

Ethylmalonic acid

1.38-6.67

1.27-5.11

1.39-6.64

1.28-4.88

1.41-6.59

1.28-4.69

n-Butyrylglycine

0.21-0.84

0.20-0.68

0.21-0.83

0.20-0.67

0.21-0.82

0.20-0.66

2-Methylsuccinic acid

0.58-2.54

0.57-2.21

0.59-2.54

0.57-2.17

0.59-2.53

0.58-2.14

2-Methylbutyrylglycine

0.11-0.85

0.12-0.75

0.11-0.85

0.12-0.73

0.11-0.85

0.12-0.71

Isovalerylglycine

0.56-3.94

0.56-3.94

0.56-3.88

0.56-3.88

0.55-3.82

0.55-3.82

Glutaric acid

0.34-1.78

0.36-1.19

0.34-1.73

0.36-1.18

0.34-1.69

0.35-1.17

3-Methylcrotonylglycine

0.32-0.80

0.32-0.80

0.32-0.80

0.32-0.80

0.32-0.80

0.32-0.80

n-Tiglylglycine

1.00-2.48

1.00-2.48

1.00-2.45

1.00-2.45

1.00-2.43

1.00-2.43

3-Methylglutaconic acid

2.78-6.58

2.78-6.58

2.82-6.49

2.82-6.49

2.82-6.39

2.82-6.39

n-Hexanoylglycine

0.27-1.21

0.30-0.90

0.27-1.21

0.30-0.89

0.28-1.20

0.30-0.88

n-Octanoylglycine

0.17-1.25

0.17-1.25

0.17-1.24

0.17-1.24

0.18-1.23

0.18-1.23

3-Phenylpropionylglycine

0.11-0.93

0.13-0.83

0.12-0.92

0.14-0.82

0.12-0.92

0.14-0.81

trans-Cinnamoylglycine

0.40-4.06

0.40-2.44

0.41-4.06

0.41-2.37

0.42-4.06

0.42-2.32

Suberylglycine

0.28-2.10

0.28-2.10

0.28-2.08

0.28-2.08

0.29-2.06

0.29-2.06

Dodecanedioic acid

0.01-0.05

0.01-0.05

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

Tetradecanedioic acid

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

Hexadecanedioic acid

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

 

 

30 Years

31 Years

32 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.15-0.64

0.15-0.64

0.16-0.62

0.16-0.62

0.16-0.60

0.16-0.60

n-Propionylglycine

0.19-0.52

0.19-0.52

0.20-0.50

0.20-0.50

0.20-0.49

0.20-0.49

Isobutyrylglycine

0.21-1.60

0.22-1.37

0.21-1.59

0.22-1.36

0.21-1.58

0.22-1.35

Ethylmalonic acid

1.42-6.54

1.28-4.54

1.43-6.48

1.29-4.42

1.44-6.42

1.29-4.32

n-Butyrylglycine

0.21-0.81

0.20-0.66

0.21-0.80

0.20-0.66

0.22-0.79

0.20-0.66

2-Methylsuccinic acid

0.60-2.52

0.58-2.10

0.60-2.50

0.58-2.05

0.61-2.47

0.58-2.01

2-Methylbutyrylglycine

0.11-0.85

0.12-0.70

0.11-0.85

0.12-0.69

0.11-0.85

0.12-0.68

Isovalerylglycine

0.55-3.77

0.55-3.77

0.54-3.72

0.54-3.72

0.53-3.68

0.53-3.68

Glutaric acid

0.35-1.65

0.35-1.17

0.35-1.61

0.35-1.17

0.35-1.58

0.35-1.17

3-Methylcrotonylglycine

0.32-0.79

0.32-0.79

0.31-0.79

0.31-0.79

0.31-0.78

0.31-0.78

n-Tiglylglycine

0.99-2.41

0.99-2.41

0.98-2.39

0.98-2.39

0.97-2.37

0.97-2.37

3-Methylglutaconic acid

2.80-6.30

2.80-6.30

2.77-6.21

2.77-6.21

2.71-6.13

2.71-6.13

n-Hexanoylglycine

0.28-1.20

0.29-0.87

0.28-1.20

0.29-0.86

0.29-1.20

0.28-0.85

n-Octanoylglycine

0.18-1.22

0.18-1.22

0.18-1.21

0.18-1.21

0.18-1.19

0.18-1.19

3-Phenylpropionylglycine

0.12-0.92

0.14-0.80

0.12-0.91

0.14-0.80

0.12-0.91

0.13-0.79

trans-Cinnamoylglycine

0.43-4.05

0.43-2.28

0.44-4.05

0.44-2.25

0.45-4.04

0.44-2.24

Suberylglycine

0.29-2.04

0.29-2.04

0.30-2.02

0.30-2.02

0.30-1.99

0.30-1.99

Dodecanedioic acid

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

Tetradecanedioic acid

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

Hexadecanedioic acid

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

 

 

33 Years

34 Years

35 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.16-0.59

0.16-0.59

0.17-0.58

0.17-0.58

0.17-0.56

0.17-0.56

n-Propionylglycine

0.20-0.48

0.20-0.48

0.21-0.47

0.21-0.47

0.21-0.46

0.21-0.46

Isobutyrylglycine

0.21-1.57

0.22-1.35

0.22-1.56

0.23-1.35

0.22-1.55

0.23-1.35

Ethylmalonic acid

1.45-6.35

1.29-4.24

1.45-6.28

1.30-4.18

1.45-6.22

1.30-4.12

n-Butyrylglycine

0.22-0.78

0.21-0.66

0.22-0.77

0.21-0.65

0.22-0.77

0.22-0.65

2-Methylsuccinic acid

0.61-2.44

0.58-1.96

0.61-2.41

0.58-1.92

0.61-2.38

0.58-1.88

2-Methylbutyrylglycine

0.11-0.85

0.11-0.67

0.11-0.85

0.11-0.66

0.11-0.85

0.11-0.66

Isovalerylglycine

0.52-3.65

0.52-3.65

0.51-3.62

0.51-3.62

0.50-3.60

0.50-3.60

Glutaric acid

0.35-1.55

0.35-1.16

0.35-1.53

0.35-1.16

0.36-1.52

0.35-1.15

3-Methylcrotonylglycine

0.31-0.77

0.31-0.77

0.30-0.76

0.30-0.76

0.30-0.75

0.30-0.75

n-Tiglylglycine

0.96-2.35

0.96-2.35

0.95-2.33

0.95-2.33

0.95-2.30

0.95-2.30

3-Methylglutaconic acid

2.66-6.05

2.66-6.05

2.60-5.97

2.60-5.97

2.54-5.89

2.54-5.89

n-Hexanoylglycine

0.29-1.19

0.28-0.84

0.29-1.19

0.28-0.84

0.30-1.18

0.28-0.83

n-Octanoylglycine

0.18-1.18

0.18-1.18

0.17-1.17

0.17-1.17

0.17-1.16

0.17-1.16

3-Phenylpropionylglycine

0.12-0.90

0.13-0.78

0.12-0.90

0.13-0.77

0.12-0.89

0.13-0.77

trans-Cinnamoylglycine

0.46-4.02

0.45-2.22

0.46-4.01

0.45-2.21

0.47-3.99

0.46-2.20

Suberylglycine

0.31-1.97

0.31-1.97

0.31-1.95

0.31-1.95

0.31-1.92

0.31-1.92

Dodecanedioic acid

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

Tetradecanedioic acid

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

Hexadecanedioic acid

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

 

 

36 Years

37 Years

38 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.17-0.56

0.17-0.56

0.18-0.55

0.18-0.55

0.18-0.54

0.18-0.54

n-Propionylglycine

0.21-0.45

0.21-0.45

0.21-0.45

0.21-0.45

0.21-0.44

0.21-0.44

Isobutyrylglycine

0.22-1.54

0.23-1.35

0.22-1.52

0.24-1.34

0.22-1.51

0.25-1.33

Ethylmalonic acid

1.45-6.16

1.30-4.06

1.45-6.11

1.31-4.01

1.45-6.07

1.31-3.95

n-Butyrylglycine

0.22-0.76

0.22-0.64

0.22-0.76

0.22-0.64

0.22-0.76

0.23-0.63

2-Methylsuccinic acid

0.61-2.35

0.58-1.84

0.61-2.33

0.58-1.81

0.61-2.31

0.58-1.78

2-Methylbutyrylglycine

0.12-0.85

0.11-0.66

0.12-0.85

0.11-0.66

0.12-0.84

0.11-0.66

Isovalerylglycine

0.50-3.59

0.50-3.59

0.49-3.58

0.49-3.58

0.49-3.58

0.49-3.58

Glutaric acid

0.36-1.50

0.35-1.14

0.36-1.50

0.35-1.13

0.36-1.49

0.36-1.12

3-Methylcrotonylglycine

0.30-0.75

0.30-0.75

0.30-0.74

0.30-0.74

0.30-0.73

0.30-0.73

n-Tiglylglycine

0.94-2.27

0.94-2.27

0.94-2.24

0.94-2.24

0.94-2.20

0.94-2.20

3-Methylglutaconic acid

2.49-5.81

2.49-5.81

2.45-5.74

2.45-5.74

2.42-5.69

2.42-5.69

n-Hexanoylglycine

0.30-1.17

0.28-0.83

0.30-1.16

0.28-0.82

0.30-1.15

0.29-0.82

n-Octanoylglycine

0.17-1.15

0.17-1.15

0.17-1.13

0.17-1.13

0.17-1.12

0.17-1.12

3-Phenylpropionylglycine

0.12-0.88

0.13-0.76

0.12-0.88

0.13-0.75

0.11-0.87

0.13-0.75

trans-Cinnamoylglycine

0.47-3.98

0.47-2.17

0.46-3.96

0.47-2.14

0.46-3.95

0.48-2.09

Suberylglycine

0.31-1.90

0.31-1.90

0.32-1.88

0.32-1.88

0.32-1.86

0.32-1.86

Dodecanedioic acid

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

Tetradecanedioic acid

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.02

0.01-0.02

Hexadecanedioic acid

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

 

 

39 Years

40 Years

41 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.18-0.54

0.18-0.54

0.18-0.54

0.18-0.54

0.18-0.54

0.18-0.54

n-Propionylglycine

0.20-0.44

0.20-0.44

0.20-0.44

0.20-0.44

0.19-0.44

0.19-0.44

Isobutyrylglycine

0.22-1.49

0.25-1.32

0.23-1.48

0.26-1.31

0.24-1.46

0.26-1.30

Ethylmalonic acid

1.44-6.04

1.32-3.90

1.44-6.01

1.33-3.86

1.43-5.98

1.34-3.82

n-Butyrylglycine

0.22-0.76

0.23-0.63

0.22-0.76

0.24-0.62

0.22-0.76

0.24-0.61

2-Methylsuccinic acid

0.61-2.29

0.59-1.76

0.61-2.28

0.59-1.74

0.62-2.27

0.60-1.72

2-Methylbutyrylglycine

0.12-0.84

0.11-0.66

0.13-0.84

0.11-0.66

0.13-0.84

0.11-0.65

Isovalerylglycine

0.49-3.57

0.49-3.57

0.49-3.57

0.49-3.57

0.49-3.56

0.49-3.56

Glutaric acid

0.36-1.49

0.36-1.10

0.36-1.49

0.36-1.09

0.36-1.49

0.37-1.07

3-Methylcrotonylglycine

0.30-0.73

0.30-0.73

0.30-0.73

0.30-0.73

0.30-0.73

0.30-0.73

n-Tiglylglycine

0.95-2.16

0.95-2.16

0.95-2.12

0.95-2.12

0.96-2.09

0.96-2.09

3-Methylglutaconic acid

2.40-5.64

2.40-5.64

2.38-5.60

2.38-5.60

2.36-5.57

2.36-5.57

n-Hexanoylglycine

0.31-1.14

0.29-0.82

0.31-1.13

0.30-0.81

0.31-1.12

0.30-0.81

n-Octanoylglycine

0.17-1.11

0.17-0.11

0.17-1.09

0.17-1.09

0.17-1.08

0.17-1.08

3-Phenylpropionylglycine

0.11-0.87

0.14-0.74

0.11-0.86

0.14-0.73

0.11-0.86

0.14-0.73

trans-Cinnamoylglycine

0.46-3.94

0.49-2.04

0.45-3.93

0.50-1.98

0.44-3.92

0.51-1.92

Suberylglycine

0.32-1.84

0.32-1.84

0.32-1.83

0.32-1.83

0.33-1.81

0.33-1.81

Dodecanedioic acid

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

Tetradecanedioic acid

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

Hexadecanedioic acid

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

 

 

42 Years

43 Years

44 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.17-0.53

0.17-0.53

0.17-0.53

0.17-0.53

0.17-0.53

0.17-0.53

n-Propionylglycine

0.19-0.44

0.19-0.44

0.19-0.44

0.19-0.44

0.18-0.44

0.18-0.44

Isobutyrylglycine

0.25-1.44

0.27-1.28

0.26-1.43

0.27-1.27

0.27-1.42

0.27-1.25

Ethylmalonic acid

1.43-5.95

1.35-3.77

1.42-5.91

1.37-3.74

1.42-5.85

1.38-3.69

n-Butyrylglycine

0.22-0.76

0.25-0.61

0.22-0.76

0.25-0.60

0.23-0.76

0.25-0.60

2-Methylsuccinic acid

0.62-2.26

0.61-1.71

0.63-2.26

0.62-1.70

0.64-2.25

0.63-1.68

2-Methylbutyrylglycine

0.14-0.84

0.11-0.65

0.14-0.84

0.11-0.64

0.15-0.84

0.11-0.63

Isovalerylglycine

0.49-3.54

0.49-3.54

0.49-3.51

0.49-3.51

0.49-3.48

0.49-3.48

Glutaric acid

0.36-1.49

0.37-1.05

0.37-1.49

0.38-1.03

0.37-1.49

0.38-1.01

3-Methylcrotonylglycine

0.31-0.73

0.31-0.73

0.31-0.73

0.31-0.73

0.31-0.73

0.31-0.73

n-Tiglylglycine

0.97-2.05

0.97-2.05

0.98-2.03

0.98-2.03

0.99-2.01

0.99-2.01

3-Methylglutaconic acid

2.35-5.54

2.35-5.54

2.34-5.53

2.34-5.53

2.33-5.52

2.33-5.52

n-Hexanoylglycine

0.32-1.11

0.31-0.81

0.32-1.11

0.32-0.81

0.32-1.10

0.33-0.81

n-Octanoylglycine

0.18-1.07

0.18-1.07

0.18-1.07

0.18-1.07

0.18-1.06

0.18-1.06

3-Phenylpropionylglycine

0.11-0.86

0.14-0.73

0.11-0.86

0.15-0.72

0.11-0.86

0.15-0.71

trans-Cinnamoylglycine

0.44-3.91

0.52-1.87

0.44-3.89

0.54-1.82

0.44-3.87

0.55-1.78

Suberylglycine

0.33-1.81

0.33-1.81

0.33-1.80

0.33-1.80

0.34-1.80

0.34-1.80

Dodecanedioic acid

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

Tetradecanedioic acid

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

Hexadecanedioic acid

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

 

 

45 Years

46 Years

47 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.17-0.53

0.17-0.53

0.17-0.53

0.17-0.53

0.17-0.53

0.17-0.53

n-Propionylglycine

0.18-0.43

0.18-0.43

0.18-0.43

0.18-0.43

0.18-0.43

0.18-0.43

Isobutyrylglycine

0.29-1.40

0.27-1.23

0.30-1.39

0.26-1.22

0.32-1.39

0.26-1.20

Ethylmalonic acid

1.42-5.78

1.40-3.65

1.42-5.70

1.42-3.60

1.42-5.60

1.43-3.55

n-Butyrylglycine

0.23-0.75

0.25-0.60

0.24-0.75

0.25-0.59

0.24-0.74

0.25-0.59

2-Methylsuccinic acid

0.65-2.25

0.63-1.67

0.66-2.24

0.64-1.65

0.67-2.23

0.65-1.63

2-Methylbutyrylglycine

0.15-0.84

0.11-0.62

0.15-0.84

0.11-0.61

0.16-0.84

0.11-0.60

Isovalerylglycine

0.49-3.45

0.49-3.45

0.49-3.40

0.49-3.40

0.49-3.36

0.49-3.36

Glutaric acid

0.37-1.47

0.39-0.99

0.37-1.46

0.39-0.97

0.38-1.44

0.40-0.95

3-Methylcrotonylglycine

0.31-0.73

0.31-0.73

0.32-0.73

0.32-0.73

0.32-0.73

0.32-0.73

n-Tiglylglycine

1.00-2.00

1.00-2.00

1.02-1.99

1.02-1.99

1.04-1.99

1.04-1.99

3-Methylglutaconic acid

2.33-5.52

2.33-5.52

2.34-5.51

2.34-5.51

2.35-5.51

2.35-5.51

n-Hexanoylglycine

0.33-1.09

0.33-0.80

0.34-1.09

0.34-0.80

0.34-1.08

0.35-0.80

n-Octanoylglycine

0.19-1.06

0.19-1.06

0.19-1.05

0.19-1.05

0.20-1.05

0.20-1.05

3-Phenylpropionylglycine

0.11-0.86

0.15-0.70

0.11-0.86

0.15-0.69

0.12-0.85

0.15-0.68

trans-Cinnamoylglycine

0.44-3.84

0.56-1.75

0.45-3.80

0.57-1.73

0.45-3.76

0.58-1.72

Suberylglycine

0.34-1.79

0.34-1.79

0.35-1.79

0.35-1.79

0.36-1.79

0.36-1.79

Dodecanedioic acid

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

Tetradecanedioic acid

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

Hexadecanedioic acid

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

 

 

48 Years

49 Years

50 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.18-0.53

0.18-0.53

0.19-0.53

0.19-0.53

0.19-0.53

0.19-0.53

n-Propionylglycine

0.18-0.42

0.18-0.42

0.18-0.42

0.18-0.42

0.18-0.42

0.18-0.42

Isobutyrylglycine

0.34-1.38

0.25-1.19

0.35-1.37

0.24-1.18

0.36-1.35

0.24-1.17

Ethylmalonic acid

1.43-5.50

1.44-3.49

1.43-5.40

1.45-3.44

1.43-5.31

1.46-3.38

n-Butyrylglycine

0.25-0.73

0.25-0.59

0.26-0.72

0.25-0.59

0.26-0.70

0.25-0.59

2-Methylsuccinic acid

0.69-2.21

0.66-1.61

0.70-2.20

0.66-1.59

0.72-2.18

0.67-1.57

2-Methylbutyrylglycine

0.16-0.84

0.11-0.59

0.16-0.84

0.11-0.59

0.16-0.83

0.11-0.58

Isovalerylglycine

0.50-3.31

0.50-3.31

0.50-3.26

0.50-3.26

0.51-3.21

0.51-3.21

Glutaric acid

0.38-1.41

0.41-0.94

0.38-1.38

0.41-0.92

0.39-1.34

0.41-0.91

3-Methylcrotonylglycine

0.32-0.73

0.32-0.73

0.32-0.72

0.32-0.72

0.32-0.71

0.32-0.71

n-Tiglylglycine

1.05-1.99

1.05-1.99

1.07-1.99

1.07-1.99

1.09-1.99

1.09-1.99

3-Methylglutaconic acid

2.36-5.50

2.36-5.50

2.37-5.49

2.37-5.49

2.38-5.46

2.38-5.46

n-Hexanoylglycine

0.35-1.07

0.35-0.80

0.36-1.07

0.36-0.79

0.36-1.06

0.36-0.79

n-Octanoylglycine

0.20-1.04

0.20-1.04

0.21-1.04

0.21-1.04

0.21-1.04

0.21-1.04

3-Phenylpropionylglycine

0.12-0.85

0.15-0.67

0.13-0.85

0.15-0.66

0.14-0.84

0.15-0.65

trans-Cinnamoylglycine

0.46-3.71

0.58-1.71

0.48-3.66

0.59-1.70

0.49-3.61

0.60-1.69

Suberylglycine

0.36-1.78

0.36-1.78

0.37-1.78

0.37-1.78

0.37-1.77

0.37-1.77

Dodecanedioic acid

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.04

0.01-0.03

0.01-0.03

Tetradecanedioic acid

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

Hexadecanedioic acid

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

 

 

51 Years

52 Years

53 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.20-0.52

0.20-0.52

0.21-0.51

0.21-0.51

0.23-0.51

0.23-0.51

n-Propionylglycine

0.19-0.41

0.19-0.41

0.19-0.41

0.19-0.41

0.19-0.41

0.19-0.41

Isobutyrylglycine

0.37-1.34

0.23-1.16

0.38-1.32

0.23-1.15

0.38-1.29

0.23-1.14

Ethylmalonic acid

1.44-5.23

1.47-3.33

1.45-5.16

1.47-3.28

1.46-5.11

1.48-3.24

n-Butyrylglycine

0.27-0.69

0.25-0.58

0.28-0.68

0.25-0.58

0.28-0.67

0.25-0.58

2-Methylsuccinic acid

0.74-2.16

0.67-1.54

0.76-2.14

0.67-1.53

0.78-2.13

0.67-1.51

2-Methylbutyrylglycine

0.16-0.83

0.11-0.58

0.16-0.82

0.11-0.58

0.16-0.80

0.11-0.58

Isovalerylglycine

0.52-3.17

0.52-3.17

0.53-3.12

0.53-3.12

0.54-3.08

0.54-3.08

Glutaric acid

0.39-1.30

0.41-0.90

0.39-1.27

0.41-0.89

0.40-1.23

0.41-0.89

3-Methylcrotonylglycine

0.32-0.70

0.32-0.70

0.32-0.68

0.32-0.68

0.32-0.67

0.32-0.67

n-Tiglylglycine

1.11-1.99

1.11-1.99

1.12-1.98

1.12-1.98

1.12-1.97

1.12-1.97

3-Methylglutaconic acid

2.39-5.42

2.39-5.42

2.40-5.36

2.40-5.36

2.40-5.28

2.40-5.28

n-Hexanoylglycine

0.37-1.05

0.36-0.78

0.38-1.04

0.36-0.78

0.38-1.03

0.36-0.77

n-Octanoylglycine

0.22-1.03

0.22-1.03

0.22-1.02

0.22-1.02

0.22-1.02

0.22-1.02

3-Phenylpropionylglycine

0.14-0.84

0.15-0.64

0.15-0.83

0.15-0.63

0.15-0.82

0.16-0.63

trans-Cinnamoylglycine

0.51-3.57

0.61-1.67

0.53-3.54

0.62-1.66

0.55-3.51

0.62-1.64

Suberylglycine

0.38-1.76

0.38-1.76

0.38-1.75

0.38-1.75

0.39-1.74

0.39-1.74

Dodecanedioic acid

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

Tetradecanedioic acid

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

Hexadecanedioic acid

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

 

 

54 Years

55 Years

56 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.24-0.50

0.24-0.50

0.24-0.49

0.24-0.49

0.25-0.47

0.25-0.47

n-Propionylglycine

0.20-0.40

0.20-0.40

0.20-0.40

0.20-0.40

0.21-0.40

0.21-0.40

Isobutyrylglycine

0.38-1.26

0.23-1.13

0.38-1.22

0.23-1.12

0.37-1.19

0.23-1.11

Ethylmalonic acid

1.48-5.07

1.49-3.21

1.50-5.03

1.50-3.19

1.53-5.00

1.51-3.17

n-Butyrylglycine

0.29-0.66

0.25-0.57

0.29-0.65

0.26-0.57

0.30-0.64

0.26-0.57

2-Methylsuccinic acid

0.81-2.11

0.67-1.50

0.83-2.10

0.67-1.49

0.86-2.09

0.67-1.48

2-Methylbutyrylglycine

0.16-0.79

0.11-0.58

0.16-0.78

0.11-0.58

0.16-0.76

0.11-0.58

Isovalerylglycine

0.55-3.03

0.55-3.03

0.56-2.99

0.56-2.99

0.57-2.94

0.57-2.94

Glutaric acid

0.40-1.20

0.40-0.88

0.41-1.17

0.40-0.87

0.41-1.15

0.39-0.87

3-Methylcrotonylglycine

0.31-0.65

0.31-0.65

0.31-0.63

0.31-0.63

0.31-0.60

0.31-0.60

n-Tiglylglycine

1.12-1.94

1.12-1.94

1.12-1.92

1.12-1.92

1.11-1.88

1.11-1.88

3-Methylglutaconic acid

2.41-5.17

2.41-5.17

2.42-5.05

2.42-5.05

2.45-4.91

2.45-4.91

n-Hexanoylglycine

0.38-1.02

0.36-0.77

0.39-1.02

0.35-0.76

0.39-1.01

0.35-0.76

n-Octanoylglycine

0.23-1.01

0.23-1.01

0.23-1.00

0.23-1.00

0.23-0.98

0.23-0.98

3-Phenylpropionylglycine

0.16-0.82

0.16-0.62

0.16-0.81

0.17-0.62

0.17-0.80

0.17-0.62

trans-Cinnamoylglycine

0.57-3.49

0.62-1.63

0.59-3.47

0.62-1.61

0.62-3.45

0.62-1.59

Suberylglycine

0.39-1.73

0.39-1.73

0.40-1.72

0.40-1.72

0.41-1.71

0.41-1.71

Dodecanedioic acid

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

Tetradecanedioic acid

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

Hexadecanedioic acid

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

 

 

57 Years

58 Years

59 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.26-0.46

0.26-0.46

0.26-0.45

0.26-0.45

0.27-0.44

0.27-0.44

n-Propionylglycine

0.22-0.40

0.22-0.40

0.22-0.40

0.22-0.40

0.23-0.40

0.23-0.40

Isobutyrylglycine

0.37-1.15

0.24-1.10

0.37-1.11

0.24-1.08

0.38-1.07

0.24-1.06

Ethylmalonic acid

1.56-4.96

1.53-3.14

1.59-4.91

1.54-3.12

1.62-4.86

1.56-3.09

n-Butyrylglycine

0.30-0.64

0.27-0.56

0.30-0.63

0.27-0.56

0.31-0.63

0.28-0.56

2-Methylsuccinic acid

0.89-2.08

0.67-1.48

0.92-2.07

0.67-1.48

0.95-2.06

0.66-1.48

2-Methylbutyrylglycine

0.16-0.74

0.11-0.57

0.16-0.73

0.12-0.56

0.16-0.71

0.12-0.55

Isovalerylglycine

0.59-2.90

0.59-2.90

0.60-2.85

0.60-2.85

0.61-2.79

0.61-2.79

Glutaric acid

0.42-1.14

0.38-0.86

0.43-1.13

0.38-0.85

0.44-1.12

0.38-0.84

3-Methylcrotonylglycine

0.30-0.58

0.30-0.58

0.30-0.56

0.30-0.56

0.30-0.54

0.30-0.54

n-Tiglylglycine

1.10-1.85

1.10-1.85

1.09-1.81

1.09-1.81

1.08-1.77

1.08-1.77

3-Methylglutaconic acid

2.48-4.76

2.48-4.76

2.53-4.60

2.53-4.60

2.59-4.44

2.59-4.44

n-Hexanoylglycine

0.39-1.00

0.35-0.76

0.39-0.99

0.36-0.75

0.39-0.99

0.36-0.75

n-Octanoylglycine

0.23-0.97

0.23-0.97

0.23-0.96

0.23-0.96

0.23-0.94

0.23-0.94

3-Phenylpropionylglycine

0.17-0.79

0.17-0.62

0.17-0.78

0.18-0.61

0.18-0.77

0.18-0.61

trans-Cinnamoylglycine

0.64-3.42

0.61-1.57

0.67-3.37

0.60-1.55

0.69-3.31

0.59-1.53

Suberylglycine

0.41-1.70

0.41-1.70

0.42-1.69

0.42-1.69

0.42-1.67

0.42-1.67

Dodecanedioic acid

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

Tetradecanedioic acid

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

Hexadecanedioic acid

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

 

 

60 Years

61 Years

62 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.28-0.43

0.28-0.43

0.28-0.42

0.28-0.42

0.29-0.42

0.29-0.42

n-Propionylglycine

0.24-0.40

0.24-0.40

0.25-0.39

0.25-0.39

0.26-0.39

0.26-0.39

Isobutyrylglycine

0.38-1.03

0.24-1.05

0.39-1.00

0.24-1.03

0.41-0.98

0.25-1.01

Ethylmalonic acid

1.66-4.79

1.58-3.06

1.70-4.72

1.60-3.03

1.74-4.65

1.62-2.99

n-Butyrylglycine

0.31-0.63

0.28-0.56

0.32-0.62

0.28-0.56

0.32-0.62

0.29-0.56

2-Methylsuccinic acid

0.98-2.05

0.66-1.47

1.00-2.04

0.66-1.47

1.02-2.03

0.66-1.46

2-Methylbutyrylglycine

0.17-0.70

0.12-0.53

0.17-0.69

0.12-0.52

0.17-0.68

0.12-0.50

Isovalerylglycine

0.62-2.73

0.62-2.73

0.62-2.66

0.62-2.66

0.62-2.59

0.62-2.59

Glutaric acid

0.45-1.11

0.37-0.82

0.46-1.10

0.37-0.81

0.47-1.09

0.37-0.79

3-Methylcrotonylglycine

0.29-0.52

0.29-0.52

0.29-0.51

0.29-0.51

0.29-0.50

0.29-0.50

n-Tiglylglycine

1.07-1.74

1.07-1.74

1.06-1.71

1.06-1.71

1.06-1.70

1.06-1.70

3-Methylglutaconic acid

2.67-4.30

2.67-4.30

2.75-4.16

2.75-4.16

2.83-4.04

2.83-4.04

n-Hexanoylglycine

0.39-0.98

0.36-0.74

0.40-0.97

0.37-0.74

0.40-0.96

0.37-0.73

n-Octanoylglycine

0.23-0.92

0.23-0.92

0.23-0.90

0.23-0.90

0.23-0.89

0.23-0.89

3-Phenylpropionylglycine

0.18-0.76

0.18-0.61

0.18-0.74

0.18-0.60

0.19-0.73

0.18-0.59

trans-Cinnamoylglycine

0.71-3.22

0.58-1.51

0.72-3.12

0.57-1.49

0.73-3.00

0.55-1.48

Suberylglycine

0.43-1.66

0.43-1.66

0.43-1.64

0.43-1.64

0.43-1.62

0.43-1.62

Dodecanedioic acid

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

Tetradecanedioic acid

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

Hexadecanedioic acid

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

 

 

63 Years

64 Years

65 Years

 

Female

Male

Female

Male

Female

Male

n-Acetylglycine

0.29-0.41

0.29-0.41

0.29-0.41

0.29-0.41

0.30-0.41

0.30-0.41

n-Propionylglycine

0.27-0.39

0.27-0.39

0.28-0.39

0.28-0.39

0.28-0.38

0.28-0.38

Isobutyrylglycine

0.42-0.95

0.24-1.00

0.44-0.94

0.24-0.98

0.46-0.93

0.24-0.98

Ethylmalonic acid

1.77-4.57

1.64-2.95

1.80-4.51

1.65-2.92

1.83-4.45

1.66-2.89

n-Butyrylglycine

0.33-0.62

0.28-0.56

0.33-0.62

0.28-0.56

0.33-0.62

0.28-0.56

2-Methylsuccinic acid

1.04-2.03

0.66-1.46

1.05-2.02

0.66-1.45

1.07-2.02

0.66-1.44

2-Methylbutyrylglycine

0.18-0.67

0.13-0.49

0.18-0.66

0.13-0.47

0.19-0.65

0.13-0.46

Isovalerylglycine

0.62-2.52

0.62-2.52

0.62-2.44

0.62-2.44

0.62-2.37

0.62-2.37

Glutaric acid

0.48-1.08

0.37-0.77

0.49-1.07

0.37-0.75

0.49-1.06

0.37-0.74

3-Methylcrotonylglycine

0.29-0.49

0.29-0.49

0.30-0.48

0.30-0.48

0.30-0.48

0.30-0.48

n-Tiglylglycine

1.06-1.68

1.06-1.68

1.06-1.67

1.06-1.67

1.06-1.67

1.06-1.67

3-Methylglutaconic acid

2.91-3.94

2.91-3.94

2.99-3.86

2.99-3.86

3.05-3.80

3.05-3.80

n-Hexanoylglycine

0.41-0.95

0.38-0.73

0.42-0.95

0.38-0.72

0.43-0.94

0.38-0.72

n-Octanoylglycine

0.22-0.87

0.22-0.87

0.22-0.85

0.22-0.85

0.22-0.84

0.22-0.84

3-Phenylpropionylglycine

0.19-0.71

0.17-0.58

0.20-0.70

0.17-0.58

0.21-0.69

0.16-0.57

trans-Cinnamoylglycine

0.74-2.88

0.53-1.46

0.75-2.76

0.52-1.45

0.75-2.64

0.50-1.44

Suberylglycine

0.43-1.59

0.43-1.59

0.43-1.57

0.43-1.57

0.42-1.55

0.42-1.55

Dodecanedioic acid

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

0.01-0.03

Tetradecanedioic acid

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

0.01-0.02

Hexadecanedioic acid

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

0.01-0.01

 

 

≥ 66 Years

 

Female

Male

n-Acetylglycine

0.30-0.41

0.30-0.41

n-Propionylglycine

0.29-0.38

0.29-0.38

Isobutyrylglycine

0.46-0.92

0.24-0.97

Ethylmalonic acid

1.84-4.42

1.67-2.86

n-Butyrylglycine

0.33-0.62

0.27-0.56

2-Methylsuccinic acid

1.07-2.02

0.66-1.43

2-Methylbutyrylglycine

0.19-0.65

0.13-0.45

Isovalerylglycine

0.61-2.31

0.61-2.31

Glutaric acid

0.49-1.06

0.38-0.73

3-Methylcrotonylglycine

0.30-0.48

0.30-0.48

n-Tiglylglycine

1.07-1.67

1.07-1.67

3-Methylglutaconic acid

3.11-3.75

3.11-3.75

n-Hexanoylglycine

0.43-0.94

0.38-0.71

n-Octanoylglycine

0.21-0.82

0.21-0.82

3-Phenylpropionylglycine

0.21-0.69

0.16-0.56

trans-Cinnamoylglycine

0.75-2.58

0.50-1.43

Suberylglycine

0.42-1.52

0.42-1.52

Dodecanedioic acid

0.01-0.03

0.01-0.03

Tetradecanedioic acid

0.01-0.02

0.01-0.02

Hexadecanedioic acid

0.01-0.01

0.01-0.01

Interpretation

When abnormal results are detected, a detailed interpretation is given including an overview of the results and of their significance; a correlation to available clinical information; elements of differential diagnosis; recommendations for additional biochemical testing and in vitro confirmatory studies (enzyme assay, molecular analysis); name and phone number of key contacts who may provide these studies at Mayo Clinic or elsewhere; and a phone number to reach one of the laboratory directors in case the referring physician has additional questions.

Clinical Reference

1. Rinaldo P, Hahn SH, Matern D: Inborn errors of amino acid, organic acid, and fatty acid metabolism. In: Burtis CA, Ashwood ER, Bruns DE eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 4th ed. WB Saunders Company; 2005:2207-2247

2. Roe CR, Ding J. Mitochondrial fatty acid oxidation disorders. In: Valle D, Antonarakis S, Ballabio A, Beaudet A, Mitchell GA. eds. The Online Metabolic and Molecular Bases of Inherited Disease. McGraw-Hill; 2019. Accessed March 30, 2020. http://ommbid.mhmedical.com/content.aspx?bookid=2709&sectionid=225087274

3. Kolker S, Cazorla AG, Valayannopoulos, et al: The phenotypic spectrum of organic acidurias and urea cycle disorders. Part 1: the initial presentation. J Inherit Metab Dis. 2015;38:1041-1057. doi: 10.1007/s10545-015-9839-3

4. Tuncel AT, Boy N, Morath MA, Horster F, Mutze U, Kolker S: Organic acidurias in adults: late complications and management. J Inherit Metab Dis. 2018;41:765-776. doi: 10.1007/s10545-017-0135-2

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

82542

LOINC Code Information

Test ID Test Order Name Order LOINC Value
AGU20 Acylglycines, QN, U 50334-2

 

Result ID Test Result Name Result LOINC Value
608931 Interpretation 53718-3
608910 n-Acetylglycine In Process
608911 n-Propionylglycine 13800-8
608912 Isobutyrylglycine 38360-4
608913 Ethylmalonic acid 13741-4
608914 n-Butyrylglycine 27892-9
608915 2-Methylsuccinic acid 13777-8
608916 2-Methylbutyrylglycine 27097-5
608917 Isovalerylglycine 13766-1
608918 Glutaric acid 13748-9
608919 3-Methylcrotonylglycine 13691-1
608920 n-Tiglylglycine 13816-4
608921 3-Methylglutaconic acid 13692-9
608922 n-Hexanoylglycine 13753-9
608923 n-Octanoylglycine 38367-9
608924 3-Phenylpropionylglycine 13793-5
608925 trans-Cinnamoylglycine 38417-2
608926 Suberylglycine 13811-5
608927 Dodecanedioic acid 13732-3
608928 Tetradecanedioic acid 50333-4
608929 Hexadecanedioic acid 50332-6
608930 Reviewed By 18771-6