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HelpTest ID CDB Cadmium, Blood
Reporting Name
Cadmium, BUseful For
Detecting exposure to cadmium, a toxic heavy metal
Specimen Type
Whole bloodSpecimen Required
Patient Preparation: High concentrations of gadolinium and iodine are known to potentially interfere with most inductively coupled plasma mass spectrometry based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Container/Tube: Royal blue top (EDTA) plastic trace element blood collection tube
Specimen Volume: Full tube
Collection Instructions:
1. See Metals Analysis Specimen Collection and Transport for complete instructions.
2. Send whole blood specimen in original collection tube. Do not aliquot.
Specimen Minimum Volume
0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole blood | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Reference Values
<5.0 ng/mL
Reference values apply to all ages.
Day(s) Performed
Monday through Saturday
Test Classification
This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82300
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CDB | Cadmium, B | 5609-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 8682 | Cadmium, B | 5609-3 |
Clinical Information
The toxicity of cadmium resembles the other heavy metals (arsenic, mercury, and lead) in that it attacks the kidney; kidney dysfunction with proteinuria with slow onset (over a period of years) is the typical presentation.
Breathing the fumes of cadmium vapors leads to nasal epithelial deterioration and pulmonary congestion resembling chronic emphysema.
The most common source of chronic exposure comes from spray painting organic-based paints without a protective breathing apparatus; auto repair mechanics represent a susceptible group for cadmium toxicity. In addition, another common source of cadmium exposure is tobacco smoke.
Interpretation
Normal blood cadmium is less than 5.0 ng/mL, with most results in the range of 0.5 to 2.0 ng/mL.
Acute toxicity will be observed when the blood level exceeds 50 ng/mL.
Cautions
No significant cautionary statements
Clinical Reference
1. Moreau T, Orssaud G, Lellouch J, Claude JR, Juguet B, Festy B: Blood cadmium levels in a general population with special reference to smoking. Arch Environ Health. 1983;38(3):163-167
2. Strathmann FG, Blum LM: Toxic elements. In: Rifai N, Chiu RWK, Young I, Burnham CD, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2023:chap 44
Method Description
The metal of interest is analyzed by inductively coupled plasma mass spectrometry.(Unpublished Mayo method)
Report Available
1 to 2 daysReject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Method Name
Inductively Coupled Plasma Mass Spectrometry (ICP-MS)