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Test ID CRMP1 Cardiovascular Risk Marker Panel, Serum


Specimen Required


Patient Preparation: Fasting is preferred but not required unless directed by the ordering provider.

Collection Container/Tube: 

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 2.5 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial. Send refrigerated.


Useful For

Assessment for risk of developing cardiovascular disease, major adverse cardiovascular events, or ischemic cerebrovascular events

Profile Information

Test ID Reporting Name Available Separately Always Performed
CLDL1 Cholesterol, LDL, Calculated, S No Yes
NHDCH Cholesterol, Non-HDL, Calculated, S No Yes
APOLB Apolipoprotein B, S Yes Yes
HDCH Cholesterol, HDL, S Yes Yes
CHOL Cholesterol, Total, S Yes Yes
TRIG Triglycerides, S Yes Yes
LIPA1 Lipoprotein(a), S Yes Yes
HSCRP C-Reactive Protein, High Sens, S Yes Yes
CVINT Interpretation No Yes
INTC1 Fasting (8 HR or more) No Yes

Method Name

LIPA1, HSCRP, APOLB: Immunoturbidimetry Assay

CHOL, TRIG, HDCH: Enzymatic Colorimetric

CLDL1, HNDCH: Calculation

Reporting Name

Cardiovascular Risk Marker Panel, S

Specimen Type

Serum

Specimen Minimum Volume

1.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
  Frozen  30 days

Clinical Information

Lipoprotein cholesterol measures are essential in managing risk for atherosclerotic cardiovascular disease (ASCVD). Atherosclerosis is defined by a buildup of plaque within arterial walls. ASCVD includes coronary heart disease, strokes, and peripheral artery disease. ASCVD develops over decades and is often asymptomatic until the patient experiences a life-threatening event such as a heart attack, stroke, or aneurysm.

 

Cholesterol is a lipid that is synthesized in most tissues and actively absorbed from the diet. There is a strong association between serum cholesterol concentrations and cardiovascular disease. Cholesterol is carried in the blood by lipoproteins. Some lipoproteins carry a stronger risk of cardiovascular disease while others are associated with reduced cardiovascular risk. Total cholesterol concentration includes the sum of all "good" and "bad" cholesterol. Therefore, total cholesterol is recommended to be interpreted in context of a lipid panel that includes high-density lipoprotein cholesterol (HDL-C) and triglyceride measures.

 

Low-density lipoprotein cholesterol (LDL-C) is the primary lipoprotein responsible for atherogenic plaque. Very low-density lipoprotein cholesterol (VLDL-C) is also atherogenic and the combination of LDL-C and VLDL-C is called non-HDL-C and often referred to as "bad" cholesterol. Serum total cholesterol, LDL-C and non-HDL-C are all directly associated with risk for ASCVD.

 

HDL-C is associated with lower risk of cardiovascular disease. Excess cholesterol is actively pumped into HDL to be carried in the blood circulation and cleared by the liver in a process known as reverse cholesterol transport. For these reasons, HDL-C is often referred to as "good" cholesterol.

 

Triglycerides are oily lipids carried in the blood by lipoproteins. Triglycerides are primarily carried by VLDL, chylomicrons and remnant lipoproteins. Recent evidence supports triglycerides as an independent risk factor for ASCVD. Several conditions are associated with increased plasma triglycerides, including obesity, pregnancy, physical inactivity, excess alcohol intake, kidney disease, and diabetes. Elevated triglycerides are often associated with reduced HDL-C, insulin resistance, hypertension, fatty liver disease, and increased waist circumference. In addition to cardiovascular risk, elevated triglycerides confer a risk for acute pancreatitis.

 

Apolipoprotein B (ApoB), high-sensitivity C-reactive protein (hsCRP), and lipoprotein (a) (Lp[a]) are serological risk factors endorsed by multiple international guidelines for use in cardiovascular disease risk assessment. Several recent guidelines have suggested that clinicians utilize ApoB, hsCRP, and Lp(a) in selected persons to augment risk classification, guide intensity of risk-reduction therapy, and modulate clinical judgment when making therapeutic decision.(1-3)

Reference Values

 

Age

2-17 years

≥18 years

CALCULATED NON-HDL CHOLESTEROL (mg/dL)

**

Acceptable: <120

Borderline High: 120-144

High: ≥145

*

Desirable: <130 mg/dL

Above Desirable: 130-159 mg/dL

Borderline High: 160-189 mg/dL

High: 190-219 mg/dL

Very high: ≥220 mg/dL

CALCULATED LDL CHOLESTEROL (mg/dL)

**

Acceptable: <110

Borderline High: 110-129

High: ≥130

***

Desirable: <100

Above Desirable: 100-129

Borderline High: 130-159

High: 160-189

Very high: ≥190

HDL CHOLESTEROL (mg/dL)

**

Low: <40

Borderline Low: 40-45

Acceptable: > 45

***

Males: ≥40

Females: ≥50

 

TOTAL CHOLESTEROL (mg/dL)

**

Acceptable: <170

Borderline High: 170-199

High: ≥200

*

Desirable: < 200

Borderline High: 200 - 239

High: ≥ 240

LIPOPROTEIN (a) (nmol/L)

Not established

< 75 nmol/L

Values ≥ 75 nmol/L may suggest increased risk of coronary heart disease.

C-REACTIVE PROTEIN, HIGH SENSITVITY

*

Lower risk: <2.0 mg/L

Higher risk: ≥2.0 mg/L

Acute inflammation: >10.0 mg/L

*

Lower risk: <2.0 mg/L

Higher risk: ≥2.0 mg/L

Acute inflammation: >10.0 mg/L

APOLIPOPROTEIN B(mg/dL)

Acceptable: <90

Borderline High: 90-109

High: ≥110

Desirable: <90

Above Desirable: 90-99

Borderline High: 100-119

High: 120-139

Very High: ≥140

 

Age

2-9 years

10-17 years

≥18 years

TRIGLYCERIDES (mg/dL)

**

Acceptable: <75 

Borderline High: 75-99

High: ≥100

**

Acceptable: <90 

Borderline High: 90-129

High: ≥130

*

Normal: <150

Borderline High: 150-199

High: 200-499

Very High: ≥500

 

*National Lipid Association 2014

**Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents

***National Cholesterol Education Program (NCEP)

Interpretation

Maintaining desirable concentrations of lipids lowers atherosclerotic cardiovascular disease risk. Establishing appropriate treatment strategies and lipid goals require that blood lipid values be considered in context with other risk factors including, age, sex, smoking status, and medical history of hypertension, diabetes, and cardiovascular disease.

 

Triglycerides results of 500 mg/dL or above are severely elevated increasing the risk of pancreatitis.

Triglycerides can be lowered by increasing physical activity, low-fat diet, weight loss and/or triglyceride lowering pharmaceuticals.

 

Low high-density lipoprotein cholesterol (HDL-C) is a risk factor for cardiovascular disease.

HDL-C can be increased by the same lifestyle changes that reduce risk for cardiovascular disease; physical activity, smoking cessation, and eating healthier. However, medications that specifically increase HDL levels have failed to reduce cardiovascular disease.

Extremely low HDL values (<20 mg/dL) may indicate liver disease or inherited dyslipidemia.

 

Low-density lipoprotein cholesterol results of 190 mg/dL or above in adults (≥160 mg/dL in children) are severely elevated and may indicate familial hypercholesterolemia.

 

For non-HDL cholesterol results of 220 mg/dL or above, consider possible inherited hyperlipidemia.

Clinical Reference

1. Grundy SM, Stone NJ, Bailey AL, et al: 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019 Jun 18;139(25):e1082-e1143

2. Jacobson TA, Ito MK, Maki KC, et al: National Lipid Association recommendations for patient-centered management of dyslipidemia: Part 1-executive summary. J Clin Lipidol. 2014 Sep-Oct;8(5):473-488. doi: 10.1016/j.jacl.2014.07.007

3. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents; National Heart, Lung, and Blood Institute. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: Summary report. Pediatrics. 2011 Dec;128 Suppl 5(Suppl 5):S213-S256. doi: 10.1542/peds.2009-2107C

4. Sampson M, Ling C, Sun Q, et al: A new equation for calculation of low-density lipoprotein cholesterol in patients with normolipidemia and/or hypertriglyceridemia. JAMA Cardiol. 2020 May 1;5(5):540-548

Day(s) Performed

Monday through Sunday

Report Available

1 to 2 days

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80061-Lipid panel (includes: HDL [CPT Code 83718], total cholesterol [CPT Code 82465], and triglycerides [CPT Code 84478])

83695-Lipoprotein (a)

86141-C-reactive protein; high sensitivity (hsCRP)

82172-Apolipoprotein B

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CRMP1 Cardiovascular Risk Marker Panel, S In Process

 

Result ID Test Result Name Result LOINC Value
CVINT Interpretation 59462-2
APOLB Apolipoprotein B, S 1884-6
LIPA1 Lipoprotein(a), S 43583-4
CLDL1 Cholesterol, LDL, Calculated, S 13457-7
INTC1 Fasting (8 HR or more) 87527-8
CHOL Cholesterol, Total, S 2093-3
HDCH Cholesterol, HDL, S 2085-9
HSCRP C-Reactive Protein, High Sens, S 30522-7
NHDCH Cholesterol, Non-HDL, Calculated, S 43396-1
TRIG Triglycerides, S 2571-8