Test ID EHRCP Ehrlichia Antibody Panel, Serum
Reporting Name
Ehrlichia Ab PanelUseful For
An adjunct in the diagnosis of infection with Anaplasma phagocytophilum or Ehrlichia chaffeensis
Seroepidemiological surveys of the prevalence of the infection in certain populations
Profile Information
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
ANAP | Anaplasma phagocytophilum Ab, IgG,S | Yes | Yes |
EHRC | Ehrlichia Chaffeensis (HME) Ab, IgG | Yes | Yes |
Specimen Type
SerumSpecimen Required
Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Specimen Volume: 0.5 mL
Specimen Minimum Volume
0.25 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Serum | Refrigerated (preferred) | 14 days | |
Frozen | 14 days |
Reference Values
ANAPLASMA PHAGOCYTOPHILUM
<1:64
Reference values apply to all ages.
EHRLICHIA CHAFFEENSIS
<1:64
Reference values apply to all ages.
Day(s) and Time(s) Performed
Monday through Friday; 9 a.m.
Test Classification
This test was developed using an analyte specific reagent. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.CPT Code Information
86666 x 2
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
EHRCP | Ehrlichia Ab Panel | 77165-9 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
81157 | Anaplasma phagocytophilum Ab, IgG,S | 23877-4 |
81478 | Ehrlichia Chaffeensis (HME) Ab, IgG | 47405-6 |
Testing Algorithm
See Acute Tick-Borne Disease Testing Algorithm in Special Instructions.
Special Instructions
Clinical Information
Anaplasma phagocytophilum:
Anaplasma phagocytophilum, an intracellular rickettsia-like bacterium, preferentially infects granulocytes and forms inclusion bodies, referred to as morulae. A phagocytophilum is transmitted by Ixodes species ticks, which also transmit Borrelia burgdorferi and Babesia species. Infection with A phagocytophilum is also referred to as human granulocytic anaplasmosis (HGA) and symptoms in otherwise healthy individuals are often mild and nonspecific, including fever, myalgia, arthralgia, and nausea. Clues to the diagnosis of anaplasmosis in a patient with an acute febrile illness after tick exposure include laboratory findings of leukopenia or thrombocytopenia and elevated liver enzymes. HGA is most prevalent in the upper Midwest and in other areas of the United States that are endemic for Lyme disease.
Ehrlichia chaffeensis:
Ehrlichia chaffeensis is an intracellular rickettsia-like bacterium that preferentially infects monocytes and is sequestered in parasitophorous vacuoles referred to as morulae. Infections with E chaffeensis are also referred to as human monocytotropic ehrlichiosis (HME). E chaffeensis is transmitted by Amblyomma species ticks, which are found throughout the southeastern and south central United States.
Many cases of HME are subclinical or mild, however, the infection can be severe and life-threatening, particularly in immunosuppressed individuals. Reported mortality rates range from 2% to 3%. Fever, fatigue, malaise, headache, and other "flu-like" symptoms occur most commonly. Leukopenia, thrombocytopenia, and elevated hepatic transaminases are frequent laboratory findings.
Interpretation
A positive immunofluorescence assay (titer ≥1:64) suggests current or previous infection. In general, the higher the titer, the more likely the patient has an active infection. Four-fold rises in titer also indicate active infection.
Previous episodes of ehrlichiosis may produce a positive serology although antibody levels decline significantly during the year following infection.
Clinical Reference
Centers for Disease Control and Prevention (CDC), Division of Vector-Borne Diseases: Tickborne diseases of the United States: A Reference manual for health care providers. 4th ed. CDC; 2017
Analytic Time
Same day/1 dayMethod Name
Immunofluorescence Assay (IFA)
Forms
If not ordering electronically, complete, print, and send a Microbiology Test Request (T244) with the specimen.