Test ID LACS1 Lactate, Plasma
Advisory Information
This test does not measure D-lactate, an uncommon, often undiagnosed cause of lactic acidosis. See DLAC / D-Lactate, Plasma.
Necessary Information
Patient's age and sex are required.
Specimen Required
Container/Tube: Grey top (potassium oxalate/sodium fluoride)
Specimen Volume: 0.5 mL
Collection Instructions:
1. Collection must be at least 1 mL in a 2-mL draw tube or at least 2 mL in a 4-mL draw tube.
 2. Spin down and separate plasma from cells.
Useful For
Diagnosing and monitoring patients with lactic acidosis
Method Name
Colorimetric
Reporting Name
Lactate, PSpecimen Type
Plasma NaFl-KOxSpecimen Minimum Volume
0.25 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Plasma NaFl-KOx | Refrigerated (preferred) | 14 days | |
Ambient | 8 hours |
Clinical Information
Anaerobic glycolysis markedly increases blood lactate and causes some increase in pyruvate levels, especially with prolonged exercise. The common cause for increased blood lactate and pyruvate is anoxia resulting from such conditions as shock, pneumonia, and congestive heart failure. Lactic acidosis may also occur in renal failure and leukemia. Thiamine deficiency and diabetic ketoacidosis are associated with increased levels of lactate and pyruvate.
Lactate measurements that evaluate the acid-base status are used in the diagnosis and treatment of lactic acidosis (abnormally high acidity in the blood).
Reference Values
0-90 days (<3 months): ≤3.3 mmol/L
3-24 months: ≤3.1 mmol/L
>24 months-18 years: ≤2.2 mmol/L
>18 years: 0.5-2.2 mmol/L
Interpretation
While no definitive concentration of lactate has been established for the diagnosis of lactic acidosis, lactate concentrations exceeding 5 mmol/L and pH below 7.25 are generally considered indicative of significant lactic acidosis.
Clinical Reference
1. Mizock BA: The hepatosplanchnic area and hyperlactatemia: A tale of two lactates. Crit Care Med 2001;29(2):447-449
2. Duke T: Dysoxia and lactate. Arch Dis Child 1999;81(4):343-350
Day(s) and Time(s) Performed
Monday through Sunday; Continuously
Analytic Time
Same day/1 dayTest Classification
This test has been cleared, approved or is exempt by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
83605
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
LACS1 | Lactate, P | 2524-7 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
LACS1 | Lactate, P | 2524-7 |