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Test ID LACS1 Lactate, Plasma


Advisory Information


This test does not measure D-lactate, an uncommon, often undiagnosed cause of lactic acidosis. See DLAC / D-Lactate, Plasma.



Necessary Information


Patient's age and sex are required.



Specimen Required


Container/Tube: Grey top (potassium oxalate/sodium fluoride)

Specimen Volume: 0.5 mL

Collection Instructions:

1. Collection must be at least 1 mL in a 2-mL draw tube or at least 2 mL in a 4-mL draw tube.

 2. Spin down and separate plasma from cells.


Useful For

Diagnosing and monitoring patients with lactic acidosis

Method Name

Colorimetric

Reporting Name

Lactate, P

Specimen Type

Plasma NaFl-KOx

Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma NaFl-KOx Refrigerated (preferred) 14 days
  Ambient  8 hours

Clinical Information

Anaerobic glycolysis markedly increases blood lactate and causes some increase in pyruvate levels, especially with prolonged exercise. The common cause for increased blood lactate and pyruvate is anoxia resulting from such conditions as shock, pneumonia, and congestive heart failure. Lactic acidosis may also occur in renal failure and leukemia. Thiamine deficiency and diabetic ketoacidosis are associated with increased levels of lactate and pyruvate.

 

Lactate measurements that evaluate the acid-base status are used in the diagnosis and treatment of lactic acidosis (abnormally high acidity in the blood).

Reference Values

0-90 days (<3 months): ≤3.3 mmol/L

3-24 months: ≤3.1 mmol/L

>24 months-18 years: ≤2.2 mmol/L

>18 years: 0.5-2.2 mmol/L

Interpretation

While no definitive concentration of lactate has been established for the diagnosis of lactic acidosis, lactate concentrations exceeding 5 mmol/L and pH below 7.25 are generally considered indicative of significant lactic acidosis.

Clinical Reference

1. Mizock BA: The hepatosplanchnic area and hyperlactatemia: A tale of two lactates. Crit Care Med 2001;29(2):447-449

2. Duke T: Dysoxia and lactate. Arch Dis Child 1999;81(4):343-350

Day(s) and Time(s) Performed

Monday through Sunday; Continuously

Analytic Time

Same day/1 day

Test Classification

This test has been cleared, approved or is exempt by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

83605

LOINC Code Information

Test ID Test Order Name Order LOINC Value
LACS1 Lactate, P 2524-7

 

Result ID Test Result Name Result LOINC Value
LACS1 Lactate, P 2524-7