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Test ID MONOS Infectious Mononucleosis, Rapid Test, Serum

Reporting Name

Infectious Mono Test, S

Useful For

Rapid confirmation of a diagnosis of infectious mononucleosis

Specimen Type


Specimen Required


Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.5 mL

Specimen Minimum Volume

0.1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values


Reference values apply to all ages.

Day(s) Performed

Monday through Sunday

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
MONOS Infectious Mono Test, S 5213-4


Result ID Test Result Name Result LOINC Value
MONOS Infectious Mono Test, S 5213-4

Clinical Information

Infectious mononucleosis (IM) is a viral illness that involves reticuloendothelial tissue and is generally limited to children and young adults. IM is most commonly caused by Epstein-Barr virus. The disease is characterized by fever, sore throat, lymphadenopathy, headache, and fatigue and, on a symptomatic basis, may be confused with other diseases.


Detectable levels of unique heterophile antibodies are produced in patients with IM.


Detectable levels of the infectious mononucleosis heterophile antibody can usually be expected to occur between the sixth and tenth day following the onset of symptoms. The level usually increases through the second or third week of illness and, thereafter, can be expected to persist, gradually declining over a 12-month period.

Clinical Reference

1. Davidsohn I, Walker PH: The nature of heterophilic antibodies in infectious mononucleosis. Am J Clin Pathol. 1935;5:445-465

2. Peter J, Ray CG: Infectious mononucleosis. Pediatr Rev. 1998;19(8):276-279

3. Johannsen EC, Kaye KM: Epstein-Barr virus (infectious mononucleosis, Epstein-Barr virus-associated malignant diseases, and other diseases). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Elsevier; 2020:1872-1890

Report Available

Same day/1 to 2 days

Method Name



If not ordering electronically, complete, print, and send a Microbiology Test Request (T244) with the specimen.