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Test ID PAS8 Pediatric Allergy Screen >8 Years, Serum

Reporting Name

Pediatric Allergy Scrn >8 Yrs, S

Useful For

Establishing a diagnosis of an allergy to pediatric allergy screen

 

Defining the allergen responsible for eliciting signs and symptoms

 

Identifying allergens:

-Responsible for allergic disease and/or anaphylactic episode

-To confirm sensitization prior to beginning immunotherapy

-To investigate the specificity of allergic reactions to insect venom allergens, drugs, or chemical allergens

Profile Information

Test ID Reporting Name Available Separately Always Performed
DF House Dust Mites/D.F., IgE Yes Yes
SRW Short Ragweed, IgE Yes Yes
TIMG Timothy Grass, IgE Yes Yes
CAT Cat Epithelium, IgE Yes Yes
ALTN Alternaria Tenuis, IgE Yes Yes

Specimen Type

Serum


Advisory Information


For a listing of allergens available for testing, see Allergens - Immunoglobulin E (IgE) Antibodies in Special Instructions



Specimen Required


Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 0.7 mL for every 5 allergens requested


Specimen Minimum Volume

For 1 allergen: 0.5 mL
For more than 1 allergen: (0.05 mL x number of allergens) + 0.25 mL deadspace

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  90 days

Reference Values

Class

IgE kU/L

Interpretation

0

<0.35

Negative

1

0.35-0.69

Equivocal

2

0.70-3.49

Positive

3

3.50-17.4

Positive

4

17.5-49.9

Strongly positive

5

50.0-99.9

Strongly positive

6

≥100

Strongly positive

Reference values apply to all ages.

Day(s) and Time(s) Performed

Monday through Friday; 9 a.m.-8 p.m.

Saturday; 8 a.m.-3 p.m.

Test Classification

This test has been cleared, approved or is exempt by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86003 x 5

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PAS8 Pediatric Allergy Scrn >8 Yrs, S In Process

 

Result ID Test Result Name Result LOINC Value
ALTN Alternaria Tenuis, IgE 6020-2
CAT Cat Epithelium, IgE 6833-8
DF House Dust Mites/D.F., IgE 6095-4
SRW Short Ragweed, IgE 6085-5
TIMG Timothy Grass, IgE 6265-3

Clinical Information

Clinical manifestations of immediate hypersensitivity (allergic) diseases are caused by the release of proinflammatory mediators (histamine, leukotrienes, and prostaglandins) from immunoglobulin E (IgE)-sensitized effector cells (mast cells and basophils) when cell-bound IgE antibodies interact with allergen.

 

In vitro serum testing for IgE antibodies provides an indication of the immune response to allergen(s) that may be associated with allergic disease.

 

The allergens chosen for testing often depend upon the age of the patient, history of allergen exposure, season of the year, and clinical manifestations. In individuals predisposed to develop allergic disease(s), the sequence of sensitization and clinical manifestations proceed as follows: eczema and respiratory disease (rhinitis and bronchospasm) in infants and children less than 5 years due to food sensitivity (milk, egg, soy, and wheat proteins) followed by respiratory disease (rhinitis and asthma) in older children and adults due to sensitivity to inhalant allergens (dust mite, mold, and pollen inhalants).

Clinical Reference

Homburger HA, Hamilton RG: Chapter 55: Allergic diseases. In Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd edition. Edited by RA McPherson, MR Pincus. Elsevier, 2017, pp 1057-1070

Analytic Time

Same day

Method Name

Fluorescence Enzyme Immunoassay (FEIA)