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Test ID SASP Aspergillus fumigatus, IgG Antibodies, Serum

Reporting Name

Aspergillus fumigatus, IgG Ab, S

Useful For

Evaluation of patients suspected of having lung disease caused by Aspergillus fumigatus

Specimen Type

Serum


Specimen Required


Container/Tube: 

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.5 mL


Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Reference Values

<4 years: not established

≥4 years: ≤102 mg/L

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

86606

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SASP Aspergillus fumigatus, IgG Ab, S 26954-8

 

Result ID Test Result Name Result LOINC Value
SASP Aspergillus fumigatus, IgG Ab, S 26954-8

Clinical Information

Aspergillus fumigatus is one of the causative agents of hypersensitivity pneumonitis (HP), as well as invasive lung disease with cavitation or pneumonitis and allergic bronchopulmonary disease.(1) Other causative microorganisms of HP include Micropolyspora faeni and Thermoactinomyces vulgaris. The development of HP and allergic bronchopulmonary disease caused by Aspergillus fumigatus is accompanied by an immune response to Aspergillus fumigatus antigens with production of IgG or IgE antibodies, respectively. While the immunopathogenesis of HP and allergic bronchopulmonary disease is not known, several immune mechanisms are postulated to play a role, including both cellular and humoral mechanisms.

Interpretation

Elevated concentrations of IgG antibodies to Aspergillus fumigatus, Thermoactinomyces vulgaris, or Micropolyspora faeni in patients with signs and symptoms of hypersensitivity pneumonitis may be consistent with disease caused by exposure to 1 or more of these organic antigens.

Clinical Reference

1. Fink JN, Zacharisen MC: Chapter 69: Hypersensitivity pneumonitis. In Allergy Principles and Practice. Vol 1. Fifth edition. Edited by E Middleton Jr, CE Reed, EF Ellis, et al. St. Louis, Mosby Year Book Inc, 1998

2. Girard M, Lacasse Y, Cormier Y: Hypersensitivity pneumonitis. Allergy 2009;64:322-334

3. Grunes D, Beasley MB: Hypersensitivity pneumonitis: A review and update of histologic findings. J Clin Pathol 2013;66:888-895

Analytic Time

Same day/1 day

Method Name

Fluorescence Enzyme Immunoassay (FEIA)

Day(s) and Time(s) Performed

Monday through Friday; 4 p.m.

Saturday; 9 a.m. - 3 p.m.