Sign in →

Test ID VDSF VDRL, Spinal Fluid

Reporting Name

VDRL, CSF

Useful For

Aiding in the diagnosis of neurosyphilis

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

CSF


Specimen Required


Collection Container/Tube: Sterile vial

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL


Specimen Minimum Volume

0.2 mL

Specimen Stability Information

Specimen Type Temperature Time
CSF Frozen (preferred) 14 days
  Refrigerated  14 days

Reference Values

Negative

Reference values apply to all ages.

Day(s) and Time(s) Performed

Monday through Friday; 12 p.m.

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86592

LOINC Code Information

Test ID Test Order Name Order LOINC Value
VDSF VDRL, CSF 5290-2

 

Result ID Test Result Name Result LOINC Value
9028 VDRL, CSF 5290-2

Clinical Information

The Venereal Disease Research Laboratory (VDRL) is a nontreponemal serologic test for syphilis that uses a cardiolipin-cholesterol-lecithin antigen to detect reaginic antibodies. The VDRL test performed on cerebrospinal fluid (CSF) can be used to diagnose neurosyphilis in patients with a prior history of syphilis infection.

 

The presence of neurosyphilis in untreated patients can be detected by the presence of pleocytosis, elevated protein, and a positive VDRL.

Interpretation

A positive Venereal Disease Research Laboratories (VDRL) on spinal fluid is highly specific for neurosyphilis.

 

A single negative VDRL result should not be used to exclude neurosyphilis and repeat testing on a new specimen may be necessary.

 

Positive results will be titered.

Cautions

The Venereal Disease Research Laboratories (VDRL) on spinal fluid gives a high percentage of false-negatives.

Clinical Reference

Miller JN: Value and limitations of nontreponemal and treponemal tests in the laboratory diagnosis of syphilis. Clin Obstet Gynecol 1975;18:191-203

Analytic Time

1 day

Reject Due To

Hemolysis

Mild OK; Gross reject

Lipemia

Mild OK; Gross reject

Icterus

NA

Other

NA

NY State Approved

Yes

Method Name

Flocculation/Agglutination

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
VDSFQ VDRL Titer, CSF No No

Testing Algorithm

If this test is positive, VDRL titer will be performed at an additional charge.

 

See Meningitis/Encephalitis Panel Algorithm in Special Instructions.

Forms

If not ordering electronically, complete, print, and send a Microbiology Test Request (T244) with the specimen.